Evidence map›Paper›PMID 31840398›Full record

ArticleAging cell2020

Compromised steady-state germinal center activity with age in nonhuman primates.

Kimberly Shankwitz, Suresh Pallikkuth, Tirupataiah Sirupangi, Daniel Kirk Kvistad, Kyle Blaine Russel, Rajendra Pahwa, Lucio Gama, Richard A Koup, Li Pan, Francois Villinger and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. In Situ Characterization of Human Follicular Helper CD4 T Cells.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. The dark side of Tregs during aging.Frontiers in immunology · 2022
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Frontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kimberly ShankwitzTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
Suresh PallikkuthMicrobiology and Immunology, University of Miami Miller School Medicine, Miami, FL, USA.
Tirupataiah SirupangiNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA, USA.
Daniel Kirk KvistadMicrobiology and Immunology, University of Miami Miller School Medicine, Miami, FL, USA.
Kyle Blaine RusselMicrobiology and Immunology, University of Miami Miller School Medicine, Miami, FL, USA.
Rajendra PahwaMicrobiology and Immunology, University of Miami Miller School Medicine, Miami, FL, USA.
Lucio GamaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, USA.
Richard A KoupImmunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
Li PanMicrobiology and Immunology, University of Miami Miller School Medicine, Miami, FL, USA.
Francois VillingerNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, LA, USA.
Savita PahwaMicrobiology and Immunology, University of Miami Miller School Medicine, Miami, FL, USA.
Constantinos PetrovasTissue Analysis Core, Immunology Laboratory, Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-5067-5810
University of Miami · USUniversity of Louisiana at Lafayette · USNational Institutes of Health · US

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GWENDOLYN Barbara SCOTT · 2007 to 2026
$33.8M
Tfh and B cells in HIV/SIV pathogenesis and vaccinationZIAAI005015 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOUP, RICHARD A · 2009 to 2025
$24.1M
Resource for Nonhuman Primate Immune ReagentsR24OD010947 · OD · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI VILLINGER, FRANCOIS J · 2012 to 2025
$4.9M
Antibody Responses in Aging SIV Infected MonkeysR01AI123048 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PAHWA, SAVITA, VILLINGER, FRANCOIS J · 2015 to 2019
$4.0M
Antibody Responses in HIV and AgingR01AI108472 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PAHWA, SAVITA · 2013 to 2017
$2.9M
NIAID NIH HHS P30 AI073961NIAID NIH HHS R01 AI108472NIAID NIH HHS R01 AI123048NIH HHS AI108472NIH HHS AI123048NIH HHS R24 OD010947
6 · The paper itself

Abstract

Age-related reductions in vaccine-induced B cells in aging indicate that germinal centers (GCs), the anatomical site where the development of humoral responses takes place, may lose efficacy with age. We have investigated the baseline follicular and GC composition in nonhuman primates (NHPs) with respect to their age. There was a marked reduction in follicular area in old animals. We found significantly lower normalized numbers of follicular PD1

Indexed as

Immunity, HumoralAgingAnimalsAntigens, CDB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesForkhead Transcription FactorsGerminal CenterGranulocytesInflammationLymph NodesLymphocyte Activation Gene 3 ProteinMacaca mulattaMonocytesAntigens, CDForkhead Transcription FactorsLymphocyte Activation Gene 3 ProteinagingB cellsfolliclesTfh cells

Identifiers

PMID31840398
PMCPMC6996951
OpenAlexW2996515296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.