ArticleMetabolic brain disease2020
Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis.
Article in Metabolic brain disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Oxymatrine regulates SPHKS/S1P signaling pathway in diabetic retinopathy: an observational clinical cohort study.Scientific reports · 2026Observational
- Astrocyte Autophagy in Neurodegenerative Diseases: Current Progress in Mechanisms and Therapeutics.Neurochemical research · 2025Review
- Tauroursodeoxycholic Acid Inhibited Apoptosis and Oxidative Stress in HMolecular neurobiology · 2024Article
- Calycosin promotes axon growth by inhibiting PTPRS and alleviates spinal cord injury.Journal of molecular neuroscience : MN · 2024Article
- Neuroprotective Effects of Oxymatrine via Triggering Autophagy and Inhibiting Apoptosis Following Spinal Cord Injury in Rats.Molecular neurobiology · 2023Article
- Oxymatrine ameliorates white matter injury by modulating gut microbiota after intracerebral hemorrhage in mice.CNS neuroscience & therapeutics · 2023Article
- Three-dimensional printing of microfiber- reinforced hydrogel loaded with oxymatrine for treating spinal cord injury.International journal of bioprinting · 2023Article
- Triad1 Promotes the Inflammatory Response and Neuronal Apoptosis to Aggravate Acute Spinal Cord Injury in Rats.Computational and mathematical methods in medicine · 2022Article
- Oxymatrine Protects Chondrocytes against IL-1Evidence-based complementary and alternative medicine : eCAM · 2022Article
- MicroRNA-218 aggravates HExperimental and therapeutic medicine · 2021Article
- The protective mechanism of action of plantamajoside on a rat model of acute spinal cord injury.Experimental and therapeutic medicine · 2021Article
- The Repression of the HMGB1-TLR4-NF-κB Signaling Pathway by Safflower Yellow May Improve Spinal Cord Injury.Frontiers in neuroscience · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study was performed to examine the effect of oxymatrine (OMT) on motor functions and histopathologic changes after spinal cord injury and the mechanism underlying its neuroprotective effects. Results suggested that, OMT causes regain of lost motor function near to normal via attenuating oxidative stress, inflammatory response and cellular apoptosis. These observations were further supported by histological examination of spinal cord of rats. It also showed to regulate pro-inflammatory cytokines, Bcl2 family proteins and reduces the level of toll like receptor (TLR-4) and nuclear factor-kappa B (NF-ĸB) in concentration dependent manner. The mitogen-activated protein kinase (MAPK) pathway was also regulated by OMT after SCI. It has been suggested that, OMT promotes the recovery of motor function after SCI in rats via multiple mechanism, and this effect may be related to its anti-oxidant, anti-inflammatory and anti-apoptotic effects.
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Registered trials
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