Evidence map›Paper›PMID 31840115›Full record

ArticleHeliyon2019

Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma.

Pier Paolo Piccaluga, Mohsen Navari, Axel Visani, Flavia Rigotti, Claudio Agostinelli, Simona Righi, Erica Diani, Marco Ligozzi, Maria Carelli, Cristina Ponti and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Molecular Mechanisms of IL18 in Disease.International journal of molecular sciences · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

Pier Paolo PiccalugaDepartment of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Mohsen NavariDepartment of Medical Biotechnology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
Axel VisaniDepartment of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Flavia RigottiDepartment of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Claudio AgostinelliDepartment of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Simona RighiDepartment of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Erica DianiDepartment of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy.
Marco LigozziDepartment of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy.
Maria CarelliDepartment of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy.
Cristina PontiDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Isabella BonDepartment of Experimental, Diagnostic, and Specialty Medicine, Microbiology Unit, University of Bologna, Bologna, Italy.
Donato ZipetoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Santo LandolfoDepartment of Public Health and Microbiology, University of Turin, Turin, Italy.
Davide GibelliniDepartment of Diagnostic and Public Health, Unit of Microbiology, University of Verona, Verona, Italy.
University of Bologna · ITUniversity of Verona · ITJomo Kenyatta University of Agriculture and Technology · KEMashhad University of Medical Sciences · IRUniversity of Trieste · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IFI16, member of the IFN-inducible PYHIN-200 gene family, modulates proliferation, survival and differentiation of different cell lineages. In particular, IFI16 expression, which is regulated during the differentiation of B cells, was recently studied in B-CLL as well. Here, we compared IFI16 expression in several lymphomas including Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma and mantle cell lymphoma with respect to normal cell counterparts. We observed that IFI16 expression was significantly deregulated only in mantle cell lymphoma (p < 0.05). Notably, IFI16 was associated with the expression of genes involved in interferon response, cell cycle, cell death and proliferation and, interestingly, lipid and glucose metabolism, suggesting that IFI16 deregulation might be associated with relevant changes in cell biology. In our group of mantle cell lymphoma samples a correlation between patient survival and IFI16 expression was not detected even though mantle cell lymphoma prognosis is known to be associated with cell proliferation. Altogether, these results suggest a complex relationship between IFI16 expression and MCL which needs to be analyzed in further studies.

Indexed as

BiochemistryCancer researchCell biologyGene expressionIFI16ImmunohistochemistryMantle cell lymphomaMolecular biologyOncologyPathologyProliferation

Identifiers

PMID31840115
PMCPMC6893061
OpenAlexW2986991547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.