ArticleScience advances2019
A minimally invasive lens-free computational microendoscope.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Lensless camera: Unraveling the breakthroughs and prospects.Fundamental research · 2025Review
- Advancing the path toNeurophotonics · 2024Article
- Photonic neural probe enabled microendoscopes for light-sheet light-field computational fluorescence brain imaging.Neurophotonics · 2024Article
- Multimode fiber endoscopes for computational brain imaging.Neurophotonics · 2024Article
- Resolution-enhanced multi-core fiber imaging learned on a digital twin for cancer diagnosis.Neurophotonics · 2024Article
- Optical imaging for screening and early cancer diagnosis in low-resource settings.Nature reviews bioengineering · 2024Article
- Real-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography.Nature communications · 2022Article
- Flexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues.Nature communications · 2022Article
- An achromatic metafiber for focusing and imaging across the entire telecommunication range.Nature communications · 2022Article
- Quantitative phase imaging through an ultra-thin lensless fiber endoscope.Light, science & applications · 2022Article
- Real-time complex light field generation through a multi-core fiber with deep learning.Scientific reports · 2022Article
- Development of nano- and microdevices for the next generation of biotechnology, wearables and miniaturized instrumentation.RSC advances · 2022Review
- Recent Advances in Lensless Imaging.Optica · 2022Article
- Single-shot 3D wide-field fluorescence imaging with a Computational Miniature Mesoscope.Science advances · 2020Article
- Diffuser-based computational imaging funduscope.Optics express · 2020Article
- Computational cannula microscopy of neurons using neural networks.Optics letters · 2020Article
- Miniscope3D: optimized single-shot miniature 3D fluorescence microscopy.Light, science & applications · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Ultra-miniaturized microendoscopes are vital for numerous biomedical applications. Such minimally invasive imagers allow for navigation into hard-to-reach regions and observation of deep brain activity in freely moving animals. Conventional solutions use distal microlenses. However, as lenses become smaller and less invasive, they develop greater aberrations and restricted fields of view. In addition, most of the imagers capable of variable focusing require mechanical actuation of the lens, increasing the distal complexity and weight. Here, we demonstrate a distal lens-free approach to microendoscopy enabled by computational image recovery. Our approach is entirely actuation free and uses a single pseudorandom spatial mask at the distal end of a multicore fiber. Experimentally, this lensless approach increases the space-bandwidth product, i.e., field of view divided by resolution, by threefold over a best-case lens-based system. In addition, the microendoscope demonstrates color resolved imaging and refocusing to 11 distinct depth planes from a single camera frame without any actuated parts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.