ArticleBDJ open2019
Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children.
Article in BDJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04756557 (Caries-preventing Effect of a Hydroxyapatite-toothpaste in Adults), which is not on this map. Cited by 86 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Caries-preventing Effect of a Hydroxyapatite-toothpaste in Adults
Who cites it
86 citing papers in PubMed, 4 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- The Effectiveness of Topical Fluorides in Preventing Dental Caries in Children and Adolescents: A Systematic Review and Meta-Analysis.Oral health & preventive dentistry · 2026Pooled it
- Natural Agents for the Improvement of Gingival Health: Systematic Review and Meta-Analysis of Randomized Clinical Trials.Oral health & preventive dentistry · 2026Pooled it
- Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021Pooled it
- Effects of calcium-containing solutions on fluorescence-detectable plaque area and enamel mineral volume: an in vitro and exploratory clinical study.BMC oral health · 2026Trial
- The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial.BMC oral health · 2024Trial
- Effectiveness of Herbal, Homeopathic and Conventional Dentifrices on Dental Caries - A Double-Blind Randomised Controlled Trial.Oral health & preventive dentistry · 2023Trial
- Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial.Frontiers in public health · 2023Trial
- Home Oral Care with Biomimetic Hydroxyapatite vs. Conventional Fluoridated Toothpaste for the Remineralization and Desensitizing of White Spot Lesions: Randomized Clinical Trial.International journal of environmental research and public health · 2022Trial
- Efficacy of a Toothpaste Based on Microcrystalline Hydroxyapatite on Children with Hypersensitivity Caused by MIH: A Randomised Controlled Trial.Oral health & preventive dentistry · 2021Trial
- Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial.Scientific reports · 2021Trial
- Comparative Evaluation of the Enamel Remineralization Potential and Antibacterial Activity of Pediatric Toothpastes Containing Fluoride, Hydroxyapatite, Ozone, Propolis, and Postbiotics: An in vitro Study.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026Article
- Human Enamel Formation: A Scoping Review for Oral Health Professionals.Dentistry journal · 2026Review
- Efficacy of calcium hypophosphite toothpaste in remineralizing initial caries in vitro.BMC oral health · 2026Article
- Evaluation of microleakage and remineralization potential of a fissure sealant containing microcapsules on artificial enamel lesions: with and without adhesive application.BMC oral health · 2026Article
- The comparative evaluation for the efficacy of different remineralization agents on initial caries lesion.BMC oral health · 2026Article
- Biogenic nanohydroxyapatite derived from Channa striata fish bones using alkaline hydrolysis and calcination.Scientific reports · 2026Article
- Remineralization of early caries lesions by calcium hypophosphite in vitro: a surface microhardness study.BDJ open · 2026Article
- In vitro study on the neutralization potential of particulate hydroxyapatite in erosive acids.BDJ open · 2026Article
- Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.Biomimetics (Basel, Switzerland) · 2026Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500 ppm fluoride in promoting remineralization and inhibiting caries development. MATERIALS AND
methodsTwo enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500 ppm F
resultsPairwise comparison (baseline vs. test) indicated significant (
conclusions10% hydroxyapatite achieved comparable efficacy with 500 ppm F
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.