ArticleTherapeutic advances in chronic disease2019
Serum adenosine deaminase activity and coronary artery disease: a retrospective case-control study based on 9929 participants.
Article in Therapeutic advances in chronic disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Perturbed pediatric circulating metabolome in mild and severe dengue disease.Journal of virology · 2025Article
- Sex differences in adenosine deaminase activity associate with disparities in SARS-CoV-2 innate immunity.iScience · 2025Article
- Bioinformatic analysis of the regulatory potential of tagging SNPs provides evidence of the involvement of genes encoding the heat-resistant obscure (Hero) proteins in the pathogenesis of cardiovascular diseases.Journal of integrative bioinformatics · 2025Article
- Correlation between serum adenosine deaminase levels and risk of diabetic foot ulcers in patients with type 2 diabetes mellitus.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Biomarkers of Inflammation Increase with Tau and Neurodegeneration but not with Amyloid-β in a Heterogenous Clinical Cohort.Journal of Alzheimer's disease : JAD · 2022Article
- ADA gene haplotype is associated with coronary-in-stent-restenosis.Molecular biology reports · 2021Article
- The relationship between adenosine deaminase and heart rate-corrected QT interval in type 2 diabetic patients.Endocrine connections · 2021Article
- Inverse relationship between serum adenosine deaminase levels and islet beta cell function in patients with type 2 diabetes.Diabetology & metabolic syndrome · 2021Article
- Serum fatty acids profile and association with early-onset coronary artery disease.Therapeutic advances in chronic disease · 2021Article
- Quantitative Assessment of Serum Amino Acids and Association with Early-Onset Coronary Artery Disease.Clinical interventions in aging · 2021Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdenosine deaminase (ADA) regulates purine metabolism through the conversion of adenosine to uric acid (UA). Adenosine and UA are closely associated with cardiovascular events, but the correlation between serum ADA activity and coronary artery disease (CAD) has not been defined.
methodsWe performed a hospital-based retrospective case-control study that included a total of 5212 patients with CAD and 4717 sex- and age-matched controls. The serum activity of ADA was determined by peroxidase assays in an automatic biochemistry analyzer.
resultsSerum ADA activity in the CAD group (10.08 ± 3.57 U/l) was significantly lower than that of the control group (11.71 ± 4.20 U/l,
conclusionsSerum ADA activity is significantly attenuated in patients with CAD, particularly in MI. We propose a mechanism by which the body maintains adenosine levels to protect the cardiovascular system in the event of CAD.
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