Evidence map›Paper›PMID 31839905›Full record

ArticleJournal of extracellular vesicles2020

Large and small extracellular vesicles released by glioma cells

Anudeep Yekula, Valentina R Minciacchi, Matteo Morello, Huilin Shao, Yongil Park, Xuan Zhang, Koushik Muralidharan, Michael R Freeman, Ralph Weissleder, Hakho Lee and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of extracellular vesicles, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
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  6. Review
  7. Blood-derived APLP1Science advances · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Anudeep YekulaDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Valentina R MinciacchiDepartment of Surgery, Pathology & Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Matteo MorelloDepartment of Surgery, Pathology & Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Huilin ShaoCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Yongil ParkCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Xuan ZhangDepartment of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Koushik MuralidharanDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Michael R FreemanDepartment of Surgery, Pathology & Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Ralph WeisslederCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Hakho LeeCenter for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Bob CarterDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Xandra O BreakefieldDepartment of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dolores Di VizioDepartment of Surgery, Pathology & Laboratory Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Leonora BalajDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
Massachusetts General Hospital · USCedars-Sinai Medical Center · USCenter for Systems Biology · USHarvard University · USBoston Children's Hospital · USHealth First · US

Funding

The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHAREST, ALAIN · 1996 to 2021
$30.9M
The power of extracellular vesicles in glioblastomaR35CA232103 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS · 2018 to 2024
$6.9M
Liquid Biopsy for treatment stratification of IDH1.R132H and EGFRvIII mutant gliomasU01CA230697 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CARTER, BOB S, SKOG, JOHAN · 2018 to 2022
$4.0M
Clinical platform for high-throughput analyses of extracellular vesiclesR01CA229777 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO, SKOG, JOHAN · 2018 to 2022
$3.2M
Molecular Mechanisms of Large Oncosome-Induced Prostate Cancer Progression and MetastasisR01CA234557 · NCI · CEDARS-SINAI MEDICAL CENTER · PI DI VIZIO, DOLORES · 2019 to 2023
$2.3M
NCI NIH HHS P01 CA069246NCI NIH HHS R01 CA229777NCI NIH HHS R01 CA234557NCI NIH HHS R35 CA232103NCI NIH HHS U01 CA230697
6 · The paper itself

Abstract

Tumour cells release diverse populations of extracellular vesicles (EVs) ranging in size, molecular cargo, and function. We sought to characterize mRNA and protein content of EV subpopulations released by human glioblastoma (GBM) cells expressing a mutant form of epidermal growth factor receptor (U87

Indexed as

biomarkersExtracellular vesiclesgliomalarge extracellular vesiclessmall extracellular vesicles

Identifiers

PMID31839905
PMCPMC6896449
OpenAlexW2991580838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.