Evidence map›Paper›PMID 31839862›Full record

ReviewThe Neurohospitalist2020

A New Era of Extended Time Window Acute Stroke Interventions Guided by Imaging.

Bhavya Rehani, Simon G Ammanuel, Yi Zhang, Wade Smith, Daniel L Cooke, Steven W Hetts, S Andrew Josephson, Anthony Kim, J Claude Hemphill, William Dillon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Neurohospitalist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. A methodological review of pragmatic designs in acute stroke trials.International journal of stroke : official journal of the International Stroke Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bhavya RehaniDepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Simon G AmmanuelDepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.ORCID https://orcid.org/0000-0003-2290-2892
Yi ZhangDepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Wade SmithDepartment of Neurology, University of California San Francisco, CA, USA.
Daniel L CookeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
Steven W HettsDepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
S Andrew JosephsonDepartment of Neurology, University of California San Francisco, CA, USA.
Anthony KimDepartment of Neurology, University of California San Francisco, CA, USA.ORCID https://orcid.org/0000-0002-8095-6517
J Claude HemphillDepartment of Neurology, University of California San Francisco, CA, USA.
William DillonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is one of the most debilitating and deadliest conditions worldwide. Intravenous t-PA is the current standard treatment within 4 hours after onset of symptoms. Recent randomized controlled trials have demonstrated the efficacy of neurointerventional intra-arterial treatment in acute ischemic stroke. About 20% of acute ischemic stroke are classified as wake-up strokes, which falls out of the conventional treatment time window. New evidence suggests that some patients with longer time from symptom onset (up to 24 hours) may benefit from thrombectomy, probably in part due to variations in collateral circulation among individual patients. Advanced imaging can play a crucial role in identifying patients who could benefit from endovascular intervention presenting within extended treatment time windows. In this article, we review the advanced imaging algorithm for ischemic stroke workup in the multiple studies published to date and summarize the results of the clinical trials for late ischemic stroke that can be clinically useful.

Indexed as

acute stroke therapyCTlate onset strokeMRIstroke imagingstroke treatment

Identifiers

PMID31839862
PMCPMC6900647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.