ArticlePostepy dermatologii i alergologii2019
Impaired resolution of wheals in the skin prick test and low diamine oxidase blood level in allergic patients.
Article in Postepy dermatologii i alergologii, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Diamine Oxidase and Gastrointestinal Diseases.Biomolecules · 2026Review
- Immunohistochemical Study of Diamine Oxidase at the Upper Gastrointestinal Tract in Patients With Gastrointestinal-Mediated Food Allergy.Allergy, asthma & immunology research · 2026Article
- Article
- Histamine Intolerance: Symptoms, Diagnosis, and Beyond.Nutrients · 2024Review
- The Missing Link: A Case of Severe Adverse Reaction to Histamine in Food and Beverages.The American journal of case reports · 2022Article
- Review
- Histamine Intolerance in Children: A Narrative Review.Nutrients · 2021Review
- Histamine Intolerance: The Current State of the Art.Biomolecules · 2020Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHistamine is the major mediator of IgE- and non-IgE-mediated allergic reactions upon allergen or hapten contact. Reduced histamine degradation capacity was associated with atopic eczema as well as with non-immunological histamine intolerance. Higher blood serum histamine level concomitant with decreased intestinal diamine oxidase activity were observed in patients with food allergy.
aimTo evaluate the relationship between patients' blood diamine oxidase (DAO) activity/histamine status and their reactivity to time-resolved histamine skin prick test in respect to vulnerability to allergic diseases. MATERIAL AND
methodsFifty-three patients were examined with skin prick tests (SPT) and patch tests for suspected presence of either IgE- or non-IgE-mediated allergy. All individuals were skin prick tested with histamine and the resolution of the wheal was monitored for 50 min. Blood DAO activity and histamine concentration were measured with a radio-extraction radioimmunoassay.
resultsTime-resolved histamine skin prick testing revealed presence of wheals which were 35% larger in diameter in 47% of examined subjects at 20 min of the test. These patients exhibited significantly compromised time-course wheal resolution (wheal ≥ 3 mm at 50 min) compared to a group of patients with the normal-rate of wheal resolution (wheal = 0 mm at 50 min). Within a group of subjects exhibiting impaired wheal resolution, 61% of patients were diagnosed allergic compared to 50% in a group of patients with a normal rate of wheal resolution. Finally, allergic patients were characterized by a significantly lower DAO activity and higher histamine content compared to healthy subjects.
conclusionsThe results of this study indicate that patients with IgE- or non-IgE-mediated allergy are likely to have low DAO blood activity and may concomitantly suffer from histamine intolerance. Furthermore, our results suggest that allergic patients are more likely to develop an excessive SPT reaction. Our results emphasize caution in interpretation of the SPT results in allergic patients with diagnosed histamine intolerance or histamine/DAO activity imbalance.
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