Evidence map›Paper›PMID 31839757›Full record

ReviewDose-response : a publication of International Hormesis Society

Isolation and Detection Technologies of Extracellular Vesicles and Application on Cancer Diagnostic.

Chunyan Ma, Fan Jiang, Yifan Ma, Jinqiao Wang, Hongjuan Li, Jingjing Zhang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
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  7. Extracellular vesicles in laboratory medicine: a review and outlook.Frontiers in cell and developmental biology · 2025
    Review
  8. Review
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  11. Review
  12. Article
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  16. Emerging Advances of Detection Strategies for Tumor-Derived Exosomes.International journal of molecular sciences · 2022
    Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chunyan MaDepartment of Neurology, The First People's Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China.
Fan JiangDepartment of Rehabilitation Medicine, The First People's Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China.
Yifan MaDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.ORCID https://orcid.org/0000-0002-9371-4365
Jinqiao WangDepartment of Rehabilitation Medicine, The First People's Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China.
Hongjuan LiDepartment of Rehabilitation Medicine, The First People's Hospital of Wenling, Wenzhou Medical University, Wenling, Zhejiang, China.
Jingjing ZhangDepartment of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.ORCID https://orcid.org/0000-0002-2706-6427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vast majority of cancers are treatable when diagnosed early. However, due to the elusive trace and the limitation of traditional biopsies, most cancers have already spread widely and are at advanced stages when they are first diagnosed, causing ever-increasing mortality in the past decades. Hence, developing reliable methods for early detection and diagnosis of cancer is indispensable. Recently, extracellular vesicles (EVs), as circulating phospholipid vesicles secreted by cells, are found to play significant roles in the intercellular communication as well as the setup of tumor microenvironments and have been identified as one of the key factors in the next-generation technique for cancer diagnosis. However, EVs present in complex biofluids that contain various contaminations such as nonvesicle proteins and nonspecific EVs, resulting in the interference of screening for desired biomarkers. Therefore, applicable isolation and enrichment methods that guarantee scale-up of sample volume, purity, speed, yield, and tumor specificity are necessary. In this review, we introduce current technologies for EV separation and summarize biomarkers toward EV-based cancer liquid biopsy. In conclusion, a novel systematic isolation method that guarantees high purity, recovery rate, and tumor specificity is still missing. Besides that, a dual-model EV-based clinical trial system includes isolation and detection is a hot trend in the future due to efficient point-of-care needs. In addition, cancer-related biomarkers discovery and biomarker database establishment are essential objectives in the research field for diagnostic settings.

Indexed as

cancer diagnosticextracellular vesiclesisolation

Identifiers

PMID31839757
PMCPMC6902397

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.