Evidence map›Paper›PMID 31839745›Full record

ArticleInternational journal of medical sciences2019

SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.

Qian Wang, Shengnan Jia, Yan Jiao, Libo Xu, Ding Wang, Xuyang Chen, Xindan Hu, Hang Liang, Naiyan Wen, Shengnan Zhang and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  5. eLife · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Qian WangDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Shengnan JiaDepartment of Hepatopancreatobiliary Medicine, The Second Hospital of Jilin University, Changchun 130041, P. R. China.
Yan JiaoDepartment of Hepatobiliary and pancreatic surgery, First Hospital of Jilin University, Changchun 130021, P. R. China.
Libo XuDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Ding WangDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Xuyang ChenDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Xindan HuDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Hang LiangDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Naiyan WenDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Shengnan ZhangDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Baofeng GuoDepartment of Plastic Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, P. R.China.
Ling ZhangDepartment of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
Jilin University · CNFirst Hospital of Jilin University · CNSecond Affiliated Hospital of Jilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer is one of the most common cancers worldwide with a high incidence rate. Therefore, the molecular basis of colorectal tumorigenesis and evolution must be clarified. Structure-specific recognition protein 1 (SSRP1) is involved in transcriptional regulation, DNA damage repair, and cell cycle regulation and has been confirmed to be highly expressed in various tumor tissues, including colorectal cancer. However, the role of SSRP1 in the development of colorectal cancer remains unclear. Therefore, this study explored the role of SSRP1 in the occurrence and development of colorectal cancer. Using bioinformatics databases, including samples from the Cancer Genome Atlas (TCGA), we confirmed high

Indexed as

ApoptosisCarcinogenesisCell Line, TumorCell ProliferationColorectal NeoplasmsComputational BiologyDNA-Binding ProteinsGene Expression Regulation, NeoplasticHigh Mobility Group ProteinsHumansNeoplasm InvasivenessOncogene Protein v-aktSignal TransductionTranscriptional Elongation FactorsDNA-Binding ProteinsHigh Mobility Group ProteinsOncogene Protein v-aktSSRP1 protein, humanTranscriptional Elongation FactorsAKT pathwayapoptosisproliferationSSRP1

Identifiers

PMID31839745
PMCPMC6909804
OpenAlexW2982370163

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.