Evidence map›Paper›PMID 31839742›Full record

ArticleInternational journal of medical sciences2019

Congenital exercise ability ameliorates muscle atrophy but not spinal cord recovery in spinal cord injury mouse model.

Po-An Tai, Yi-Ju Hsu, Wen-Ching Huang, Chun-Hao Chang, Yi-Hsun Chen, Chi-Chang Huang, Li Wei

Open access · goldAbstract read
In one paragraph

Article in International journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. International journal of medical sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Po-An TaiDivision of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
Yi-Ju HsuGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Wen-Ching HuangDepartment of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei 11219, Taiwan.
Chun-Hao ChangGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Yi-Hsun ChenGraduate Institute of Veterinary Pathobiology, National Chung Hsin University, Taichung, 402, Taiwan;
Chi-Chang HuangGraduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
Li WeiDivision of Neurosurgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan.
National Taiwan Sport University · TWNational Chung Hsing University · TWNational Taipei University of Nursing and Health Science · TWTaipei Tzu Chi Hospital · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) can cause loss of mobility in the limbs, and no drugs, surgical procedures, or rehabilitation strategies provide a complete cure. Exercise capacity is thought to be associated with the causes of many diseases. However, no studies to date have assessed whether congenital exercise ability is related to the recovery of spinal cord injury. High congenital exercise ability (HE) and low congenital exercise ability (LE) mice were artificially bred from the same founder ICR mice. The HE and LE groups still exhibited differences in exercise ability after 13 generations of breeding. Histological staining and immunohistochemistry staining indicated no significant differences between the HE and LE groups on recovery of the spinal cord. In contrast, after SCI, the HE group exhibited better mobility in gait analysis and longer endurance times in the exhaustive swimming test than the LE group. In addition, after SCI, the HE group also exhibited less atrophy than the LE group, and no inflammatory cells appeared. In conclusion, we found that high congenital exercise ability may reduce the rate of muscle atrophy. This result can be applied to sports science and rehabilitation science as a reference for preventive medicine research.

Indexed as

Recovery of FunctionAnimalsDisease Models, AnimalExerciseHumansMaleMiceMuscular AtrophyPhysical Conditioning, AnimalSpinal CordSpinal Cord Injuriescongenital exercise abilitymuscle atrophyspinal cord injury

Identifiers

PMID31839742
PMCPMC6909809
OpenAlexW2982428607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.