Evidence map›Paper›PMID 31839740›Full record

ArticleInternational journal of medical sciences2019

Impact of bisphosphonates on the proliferation and gene expression of human fibroblasts.

Francisco Javier Manzano-Moreno, Rebeca Illescas-Montes, Lucia Melguizo-Rodriguez, Victor J Costela-Ruiz, Olga García-Martínez, Concepción Ruiz, Javier Ramos-Torrecillas

Abstract read
In one paragraph

Article in International journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Francisco Javier Manzano-MorenoBiomedical Group (BIO277), Department of Stomatology, School of Dentistry, University of Granada, Spain.
Rebeca Illescas-MontesBiomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences. University of Granada, Spain.
Lucia Melguizo-RodriguezBiomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences. University of Granada, Spain.
Victor J Costela-RuizBiomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences. University of Granada, Spain.
Olga García-MartínezBiomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences. University of Granada, Spain.
Concepción RuizBiomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences. University of Granada, Spain.
Javier Ramos-TorrecillasBiomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences. University of Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to elucidate the role of fibroblasts in bisphosphonate-related osteonecrosis of the jaw (BRONJ), evaluating the effect of zoledronate, alendronate, and ibandronate on the proliferation of fibroblasts and on their expression of genes essential for fibroblast physiology. Human CCD-1064Sk epithelial fibroblast cells were incubated in culture medium with 10

Indexed as

AlendronateBisphosphonate-Associated Osteonecrosis of the JawCell DifferentiationCell ProliferationDiphosphonatesFibroblastsGene Expression RegulationHumansIbandronic AcidJawOsteoblastsReal-Time Polymerase Chain ReactionZoledronic AcidAlendronateDiphosphonatesIbandronic AcidZoledronic Acidbisphosphonatesfibroblastgene expressionjawosteonecrosis

Identifiers

PMID31839740
PMCPMC6909813

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.