ArticleBiochemia medica2020
Platelet indices in stable chronic obstructive pulmonary disease - association with inflammatory markers, comorbidities and therapy.
Article in Biochemia medica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- A Nomogram for Predicting Cardiovascular Diseases in Chronic Obstructive Pulmonary Disease Patients.Journal of healthcare engineering · 2022Trial
- Epidemiological characteristics of Echinococcus granulosus infection in children from some sites in Xinjiang and its association with platelets.BMC infectious diseases · 2026Article
- Association of inflammatory scoring tools with spirometry indices in COVID-19 patients: a single center cohort study.Iranian journal of microbiology · 2025Article
- Assessment of Mean Platelet Volume as an Inflammatory Marker in Chronic Obstructive Pulmonary Disease Exacerbations.Cureus · 2025Article
- The prevalence and risk factors of pulmonary embolism in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis.Thrombosis journal · 2025Review
- Based exploration of the diagnostic value of oxidative stress-related key genes in chronic obstructive pulmonary disease.Cell biology and toxicology · 2025Article
- Article
- Platelet-based biomarkers: A new frontier in inflammation monitoring for respiratory infections.F1000Research · 2025Article
- Article
- Platelet ındices as potential biomarkers of perinatal outcomes in women with SLE during pregnancy.Archives of gynecology and obstetrics · 2024Article
- Association between systemic inflammatory markers and chronic obstructive pulmonary disease: A population-based study.Heliyon · 2024Article
- Inhibition of oxidative stress by apocynin attenuated chronic obstructive pulmonary disease progression and vascular injury by cigarette smoke exposure.British journal of pharmacology · 2023Article
- The potential of high-order features of routine blood test in predicting the prognosis of non-small cell lung cancer.BMC cancer · 2023Review
- Article
- Logistic Regression Analysis of Clinical Characteristics for Differentiation of Chronic Obstructive Pulmonary Disease Severity.Emergency medicine international · 2023Article
- Activation of NLRP3 inflammasome in stable chronic obstructive pulmonary disease.Scientific reports · 2022Article
- Influence of disease severity, smoking status and therapy regimes on leukocyte subsets and their ratios in stable chronic obstructive pulmonary disease.Archives of medical science : AMS · 2022Article
- Pulmonary embolism with chronic obstructive pulmonary disease.Chronic diseases and translational medicine · 2021Review
- Emergency admission parameters for predicting in-hospital mortality in patients with acute exacerbations of chronic obstructive pulmonary disease with hypercapnic respiratory failure.BMC pulmonary medicine · 2021Article
- IncreasedDiagnostics (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionChronic obstructive pulmonary disease (COPD) is a complex inflammatory condition that can affect haemostasis. This study aimed to determine differences in platelet-related parameters between controls and COPD subjects. The hypothesis was that platelet indices are disturbed in COPD patients, and this would be accompanied by increased C-reactive protein (CRP), fibrinogen (Fbg) and white blood cells (WBC). Therefore, platelet count (Plt), platelet-related parameters - mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (Pct), their ratios (MPV/Plt, MPV/Pct, PDW/Plt, PDW/Pct), platelet to lymphocyte ratio (PLR), Plt index as well as CRP, Fbg and WBC were assessed. MATERIALS AND
methodsStudy included 109 patients with stable COPD and 95 control subjects, recruited at Clinical Department for Lung Diseases Jordanovac, University Hospital Centre Zagreb (Zagreb, Croatia). Complete blood count was performed on Sysmex XN-1000, CRP on Cobas c501, and Fbg on BCS XP analyser. Data were analysed with MedCalc statistical software.
resultsPlatelet (P = 0.007) and PLR (P = 0.006) were increased, while other platelet indices were decreased in COPD patients compared to controls. Combined model that included PLR, PDW and WBC showed great diagnostic performances, and correctly classified 75% of cases with an AUC of 0.845 (0.788 - 0.892), P < 0.001. Comorbidities (cardiovascular or metabolic diseases) had no effect on investigated parameters, while inhaled corticosteroids/long-acting β
conclusionPlatelet indices were altered in COPD patients and they could be valuable as diagnostic markers of COPD development, especially if combined with already known inflammatory markers.
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