Evidence map›Paper›PMID 31839699›Full record

ArticleJournal of photochemistry and photobiology. A, Chemistry2019

Discovery and Characterization of Halogenated Xanthene Inhibitors of DUSP5 as Potential Photodynamic Therapeutics.

Robert D Bongard, Michael Lepley, Adam Gastonguay, Raulia R Syrlybaeva, Marat R Talipov, Rachel A Jones Lipinsky, Noah R Leigh, Jaladhi Brahmbhatt, Raman Kutty, Rajendra Rathore and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of photochemistry and photobiology. A, Chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Robert D BongardCenter for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, Concordia University Wisconsin, 12800 North Lake Shore Drive, Mequon, WI 53097.
Michael LepleyImmucor Inc., 20925 Crossroads Circle, Waukesha, WI 53186.
Adam GastonguayNelson Mullins, One Post Office Square, 30 Floor, Boston MA 02109.
Raulia R SyrlybaevaDepartment of Chemistry and Biochemistry, New Mexico State University, MSC 3C, P.O. Box 30001, Las Cruces, NM 88003.
Marat R TalipovDepartment of Chemistry and Biochemistry, New Mexico State University, MSC 3C, P.O. Box 30001, Las Cruces, NM 88003.
Rachel A Jones LipinskyDepartment of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226.
Noah R LeighMilwaukee Health Department, 841 N. Broadway, Milwaukee, WI 53202.
Jaladhi BrahmbhattEli Lilly and Company, Lilly Corporate Center Paten, Indianapolis, IN 46285.
Raman KuttyDepartment of Pediatrics, Obstetrics and Gynecology, Children's Research Institute (CRI) Developmental Vascular Biology Program, Translational and Biomedical Research Center, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226.
Rajendra RathoreDepartment of Chemistry, Marquette University, Wehr Chemistry Building, P.O. Box 1881, 535 N. 14 Street, Milwaukee, WI 53201.
Ramani Ramchandran *Department of Pediatrics, Obstetrics and Gynecology, Children's Research Institute (CRI) Developmental Vascular Biology Program, Translational and Biomedical Research Center, 8701 Watertown Plank Road, P.O. Box 26509, Milwaukee, WI 53226.
Daniel S Sem *Center for Structure-based Drug Design and Development, Department of Pharmaceutical Sciences, Concordia University Wisconsin, 12800 North Lake Shore Drive, Mequon, WI 53097.
Children's Hospital of Wisconsin · USConcordia University Wisconsin · USMarquette University · USNew Mexico State University · USCrossroads College · USEli Lilly (United States) · USMilwaukee Health Department · USNelson Engineering (United States) · US

Funding

Targeting DUSP-5 to Treat Vascular AnomaliesR01HL112639 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2012 to 2016
$2.6M
Roundabout4 signaling in endothelial cellsR01HL090712 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2009 to 2012
$1.8M
Snrk-1 and Dusp-5 co-ordinately regulate vascular development in vertebratesR01HL102745 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2011 to 2014
$1.5M
Development of ER-beta Agonists to Treat Post-Menopausal Memory DeclineR15GM118304 · NIGMS · CONCORDIA UNIVERSITY WISCONSIN · PI SEM, DANIEL S · 2015 to 2018
$820k
NHLBI NIH HHS R01 HL090712NHLBI NIH HHS R01 HL102745NHLBI NIH HHS R01 HL112639NIGMS NIH HHS R15 GM118304
6 · The paper itself

Abstract

Dual specific phosphatases (DUSPs) are an important class of mitogen-activated protein kinase (MAPK) regulators, and are drug targets for treating vascular diseases. Previously we had shown that DUSP5 plays a role in embryonic vertebrate vascular patterning. Herein, we screened a library of FDA-approved drugs and related compounds, using a

Indexed as

DUSP5enzyme kineticseosin YmerbrominpERKrose bengalxanthene dyes

Identifiers

PMID31839699
PMCPMC6910256
OpenAlexW2914573229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.