ArticleCurrent biology : CB2020
Molecular Logic and Evolution of Bitter Taste in Drosophila.
Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 94 citations in OpenAlex.
- Article
- A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026Article
- Molecular bases of insect odorant receptor function: specificity and evolution.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Metaplastic neuronal state transition regulates species-specific interoceptive processing inbioRxiv : the preprint server for biology · 2026Article
- Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Iridoids fromMolecules (Basel, Switzerland) · 2025Article
- Genomic plasticity drives olfactory adaptation in a pest fly.bioRxiv : the preprint server for biology · 2025Article
- Odorant Receptors Mediating Avoidance of Toxic Mustard Oils in Drosophila melanogaster Are Expanded in Herbivorous Relatives.Molecular biology and evolution · 2025Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Bitter Sensing ProtectsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cholesterol taste avoidance ineLife · 2025Article
- Molecular evolution of gustatory receptors in the Anopheles gambiae complex.BMC ecology and evolution · 2025Article
- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Opponent coding mechanisms in Drosophila taste neurons.Chemical senses · 2025Review
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Function and evolution of Ir52 receptors in mate detection in Drosophila.Current biology : CB · 2024Article
- Molecular Functions and Physiological Roles of Gustatory Receptors of the SilkwormInternational journal of molecular sciences · 2024Review
- Base Recording: A Technique for Analyzing Responses of Taste Neurons in Drosophila.Journal of visualized experiments : JoVE · 2024Article
- Taste evolution in an herbivorous drosophilid.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Taste systems detect a vast diversity of toxins, which are perceived as bitter. When a species adapts to a new environment, its taste system must adapt to detect new death threats. We deleted each of six commonly expressed bitter gustatory receptors (Grs) from Drosophila melanogaster. Systematic analysis revealed that requirements for these Grs differed for the same tastant in different neurons and for different tastants in the same neuron. Responses to some tastants in some neurons required four Grs, including Gr39a. Deletions also produced increased or novel responses, supporting a model of Gr-Gr inhibitory interactions. Coexpression of four Grs conferred several bitter responses to a sugar neuron. We then examined bitter coding in three other Drosophila species. We found major evolutionary shifts. One shift depended on the concerted activity of seven Grs. This work shows how the complex logic of bitter coding provides the capacity to detect innumerable hazards and the flexibility to adapt to new ones.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.