ArticleCirculation. Arrhythmia and electrophysiology2019
R-From-T as a Common Mechanism of Arrhythmia Initiation in Long QT Syndromes.
Article in Circulation. Arrhythmia and electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 58 citations in OpenAlex.
- Berberine Poisoning with Polymorphic Ventricular Tachycardia: A Case Report.Clinical practice and cases in emergency medicine · 2026Article
- Modes of onset of ventricular arrhythmias in J-wave syndromes: mechanistic insights from computational modeling.American journal of physiology. Heart and circulatory physiology · 2026Article
- Are physiological oscillations physiological?The Journal of physiology · 2026Review
- The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy.Journal of neurochemistry · 2026Review
- Population Modeling Approach for Human Cardiac Arrhythmia Risk Prediction.Circulation. Arrhythmia and electrophysiology · 2026Article
- Detecting Local Myocardial Spatiotemporal Repolarization Gradients With Clinical Mapping Arrays.Circulation. Arrhythmia and electrophysiology · 2025Article
- Methadone Blockade of Inward Rectifier Potassium Current Promotes Both Early and Delayed Repolarization Arrhythmias: Mechanistic Insights From Computational Modeling.Journal of the American Heart Association · 2025Article
- Origin of ventricular fibrillation triggers in a model of localized repolarization heterogeneity.Heart rhythm · 2025Article
- R-on-T Phenomenon Causing Cardiac Arrest in a Post-coronary Artery Bypass Graft (CABG) Patient.Cureus · 2025Article
- When ICD shocks hit like clockwork: Ventricular fibrillation induced by an atrial auto-threshold algorithm in patient with long QT syndrome type 3.HeartRhythm case reports · 2025Article
- Ultrastructure and cardiac impulse propagation: scaling up from microscopic to macroscopic conduction.The Journal of physiology · 2025Review
- Inappropriate ventricular pacing-induced ventricular fibrillation in a long QT type 3 syndrome patient with implantable cardioverter-defibrillator.HeartRhythm case reports · 2024Article
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Curvature-mediated source and sink effects on the genesis of premature ventricular complexes in long QT syndrome.American journal of physiology. Heart and circulatory physiology · 2024Article
- Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum.European heart journal · 2024Article
- Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024Review
- Mechanisms of torsades de pointes: an update.Frontiers in cardiovascular medicine · 2024Review
- Advancements in the diagnosis and management of premature ventricular contractions in pediatric patients.Frontiers in pediatrics · 2024Review
- Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy.JCI insight · 2023Article
- Regional beat-to-beat variability of repolarization increases during ischemia and predicts imminent arrhythmias in a pig model of myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundLong QT syndromes (LQTS) arise from many genetic and nongenetic causes with certain characteristic ECG features preceding polymorphic ventricular tachyarrhythmias (PVTs). However, how the many molecular causes result in these characteristic ECG patterns and how these patterns are mechanistically linked to the spontaneous initiation of PVT remain poorly understood.
methodsAnatomic human ventricle and simplified tissue models were used to investigate the mechanisms of spontaneous initiation of PVT in LQTS.
resultsSpontaneous initiation of PVT was elicited by gradually ramping up I
conclusionsDespite the complex molecular causes, these results suggest that R-from-T is likely a common mechanism for PVT initiation in LQTS. Targeting I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.