ArticleEnvironmental science and pollution research international2020
Human exposure of bisphenol A and its analogues: understandings from human urinary excretion data and wastewater-based epidemiology.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 116 citations in OpenAlex.
- Perinatal Environmental Health Education Intervention to Reduce Exposure to Endocrine Disruptors: The PREVED Project.International journal of environmental research and public health · 2021Trial
- A new multi-residue method for PFAS analysis in wastewater for environmental and public health risk assessment.Analytical and bioanalytical chemistry · 2026Article
- A Computational Framework to Evaluate Interactions of BPA and Its Analogs with Human Liver X Receptor-Beta for Health Risk Assessment.Chemical research in toxicology · 2026Article
- Occurrence Patterns of Bisphenol Analogues in Human Blood, Subcutaneous Fat, and Visceral Fat.Environment & health (Washington, D.C.) · 2026Article
- Disruption of estrogen signaling by developmental exposure to BPA and TBT causes long term functional deficits in zebrafish retina.Frontiers in pharmacology · 2026Review
- Global research on endocrine disruptors as emerging hazards for human health and the environment.Frontiers in endocrinology · 2025Review
- Role of bisphenol A in the aberrant activation of ionotropic glutamate transporters in the cerebral cortex and altered behavioral responses in C57BL/6J mice.Frontiers in toxicology · 2025Article
- Induction of fibrosis following exposure to bisphenol A and its analogues in 3D human uterine leiomyoma cultures.Journal of hazardous materials · 2024Article
- Repurposing Sewage and Toilet Systems: Environmental, Public Health, and Person-Centered Healthcare Applications.Global challenges (Hoboken, NJ) · 2024Article
- Article
- Toxicological evaluation of bisphenol analogues: preventive measures and therapeutic interventions.RSC advances · 2023Review
- Bisphenols, but not phthalate esters, modulate gene expression in activated human MAIT cellsToxicology reports · 2023Article
- A Clinical Preventive Strategy Based on a Digital Tool to Improve Access to Endocrine Disruptors Exposure Prevention: The MEDPREVED Study.International journal of environmental research and public health · 2022Article
- Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities.Environmental research · 2022Article
- Identification of biomarkers in wastewater-based epidemiology: Main approaches and analytical methods.Trends in analytical chemistry : TRAC · 2021Review
- Legislation against endocrine-disrupting compounds in drinking water: essential but not enough to ensure water safety.Environmental science and pollution research international · 2021Article
- Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart.Animals : an open access journal from MDPI · 2021Article
- Investigation of the migration of bisphenols from baby bottles and sippy cups.Current research in food science · 2021Article
- Wastewater-based epidemiology to assess human exposure to personal care and household products - A review of biomarkers, analytical methods, and applications.Trends in environmental analytical chemistry · 2020Review
- The Endocrine Disruptor Bisphenol A (BPA) Affects the Enteric Neurons Immunoreactive to Neuregulin 1 (NRG1) in the Enteric Nervous System of the Porcine Large Intestine.International journal of molecular sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
This work evaluated human exposure to bisphenol A (BPA) and its analogues based on human urinary excretion data and wastewater-based epidemiology (WBE). The results showed that the world's average human daily intake ranked from high to low is in order of bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS), bisphenol P (BPP), bisphenol AP (BPAP), bisphenol B (BPB), bisphenol Z (BPZ), and bisphenol AF (BPAF), and their corresponding human daily intakes are 2.53, 0.68, 0.60, 0.41, 0.36, 0.29, 0.24, and 0.06 μg/p/day, respectively. BPA is clearly the dominant bisphenol for human exposure. However, the results also showed that humans have been widely exposed to BPA analogues as well. Many BPA analogues showed similar estrogenic activities to those of BPA; therefore, the adverse effects of BPA and its analogues on humans should be comprehensively evaluated. The nominal exposure levels obtained based on wastewater-based epidemiology ranked high to low are in order of BPA (513.73 μg/p/day), BPF (10.20 μg/p/day), BPS (5.21 μg/p/day), BPP (1.15 μg/p/day), BPZ (0.66 μg/p/day), BPB (0.61 μg/p/day), BPAF (0.58 μg/p/day), and BPAP (0.35 μg/p/day). The world's human average daily intakes of BPA and its analogues are only 0.5-47.9% of the intakes of their corresponding human nominal exposures. This study suggests that other sources rather human excretions are important origins in municipal wastewater, which indicates that the WBE method based on parent compounds is inappropriate for evaluations of human daily intakes of BPA and its analogues, neither for other industrial compounds that have multiple important sources. Three main important sources of BPA and its analogues in municipal wastewater are likely effluents of industrial wastewater, discharges of hospital wastewater, and landfill leachates. To decrease discharges of BPA and its analogues to the natural environment, any mixing of industrial and hospital wastewater as well as landfill leachates in municipal wastewater is not favorable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.