Evidence map›Paper›PMID 31838665›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2020

Ventricular arrhythmias in patients with biventricular assist devices.

Andrew Y Lin, Hao Tran, Michela Brambatti, Eric Adler, Victor Pretorius, Travis Pollema, Jonathan C Hsu, Gregory K Feld, Kurt Hoffmayer, Frederick Han and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Mechanical circulatory support in ventricular arrhythmias.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Andrew Y LinDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Hao TranDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Michela BrambattiDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Eric AdlerDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Victor PretoriusDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr., La Jolla, CA, 92037, USA.
Travis PollemaDivision of Cardiothoracic Surgery, Department of Surgery, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr., La Jolla, CA, 92037, USA.
Jonathan C HsuDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Gregory K FeldDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Kurt HoffmayerDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Frederick HanDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
David KrummenDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA.
Gordon HoDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of California San Diego, 9452 Medical Center Dr. MC 7411, La Jolla, CA, 92037, USA. goho@ucsd.edu.ORCID http://orcid.org/0000-0001-6467-3333
University of California San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4M
American Heart Association 19CDA34760021American Heart Association-American Stroke Association 19CDA34760021NCATS NIH HHS KL2 TR001444NIH HHS 1KL2TR001444
6 · The paper itself

Abstract

purposeVentricular arrhythmias (VAs) are common in patients after left ventricular assist device (LVAD) implant and are associated with worse outcomes. However, the prevalence and impact of VA in patients with durable biventricular assist device (BIVAD) is unknown. We performed a retrospective cohort study of patients with BIVADs to evaluate the prevalence of VA and their clinical outcomes.

methodsConsecutive patients who received a BIVAD between June 2014 and July 2017 at our medical center were included. The prevalence of VA, defined as sustained ventricular tachycardia or fibrillation requiring defibrillation or ICD therapy, was compared between BIVAD patients and a propensity-matched population of patients with LVAD from our center. The occurrence of adverse clinical events was compared between BIVAD patients with and without VA.

resultsOf the 13 patients with BIVADs, 6 patients (46%) experienced clinically significant VA, similar to a propensity-matched LVAD population (38%, p = 1.00). There were no differences in baseline characteristics between the two cohorts, except patients in the non-VA group who had worse hemodynamics (mitral regurgitation and right-sided indices), had less history of VA, and were younger. BIVAD patients with VA had a higher incidence of major bleeding (MR 3.05 (1.07-8.66), p = 0.036) and worse composite outcomes (log-rank test, p = 0.046). The presence of VA was associated with worse outcomes in both LVAD and BIVAD groups.

conclusionsVentricular arrhythmias are common in patients with BIVADs and are associated with worse outcomes. Future work should assess whether therapies such as ablation improve the outcome of BIVAD patients with VA.

Indexed as

Heart-Assist DevicesHeart FailureTachycardia, VentricularHemodynamicsHumansRetrospective StudiesTreatment OutcomeBiventricular assist deviceHeart failureVentricular arrhythmiaVentricular tachycardia

Identifiers

PMID31838665
PMCPMC7293581
OpenAlexW2996276702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.