Evidence map›Paper›PMID 31838622›Full record

Trial reportObesity surgery2020

Magnesium and Ketamine Reduce Early Morphine Consumption After Open Bariatric Surgery: a Prospective Randomized Double-Blind Study.

Hicham Jabbour, Khalil Jabbour, Antoine Abi Lutfallah, Hicham Abou Zeid, Eliane Nasser-Ayoub, Marc Abou Haidar, Nicole Naccache

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  13. Magnesium and Pain.Nutrients · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hicham JabbourDepartment of Anesthesia, Critical Care and Pain Management, Hôtel-Dieu de France Hospital, Saint Joseph University School of Medicine, P.O. Box 11-5076, Beirut, 1107 2180, Lebanon.
Khalil JabbourDepartment of Anesthesia, Critical Care and Pain Management, Hôtel-Dieu de France Hospital, Saint Joseph University School of Medicine, P.O. Box 11-5076, Beirut, 1107 2180, Lebanon.
Antoine Abi LutfallahDepartment of Anesthesia, Critical Care and Pain Management, Hôtel-Dieu de France Hospital, Saint Joseph University School of Medicine, P.O. Box 11-5076, Beirut, 1107 2180, Lebanon. Antoine.abilutfallah@net.usj.edu.lb.ORCID 0000-0002-2808-0060
Hicham Abou ZeidDepartment of Anesthesia, Critical Care and Pain Management, Hôtel-Dieu de France Hospital, Saint Joseph University School of Medicine, P.O. Box 11-5076, Beirut, 1107 2180, Lebanon.
Eliane Nasser-AyoubDepartment of Anesthesia, Critical Care and Pain Management, Hôtel-Dieu de France Hospital, Saint Joseph University School of Medicine, P.O. Box 11-5076, Beirut, 1107 2180, Lebanon.
Marc Abou HaidarDepartment of Anesthesia, Critical Care and Pain Management, Hôtel-Dieu de France Hospital, Saint Joseph University School of Medicine, P.O. Box 11-5076, Beirut, 1107 2180, Lebanon.
Nicole NaccacheDepartment of Anesthesia, Critical Care and Pain Management, Hôtel-Dieu de France Hospital, Saint Joseph University School of Medicine, P.O. Box 11-5076, Beirut, 1107 2180, Lebanon.
Saint Joseph University · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundsOptimal pain management in bariatric patients is crucial for early recovery. This study aims to evaluate the effects of magnesium and ketamine combination on morphine consumption after open bariatric surgery (primary outcome), as well as on postoperative pain scores and occurrence of side effects.

methodA total of 60 patients undergoing elective open gastric bypass were randomized into 3 groups. All patients received the same general anaesthesia protocol. The magnesium and ketamine group (Mg + K) received an IV bolus of magnesium 50 mg/kg and ketamine 0.2 mg/kg followed by continuous infusion of magnesium (8 mg/kg/h) and ketamine (0.15 mg/kg/h) until extubation. The ketamine group (K) received the same bolus and infusion of ketamine, together with a bolus and continuous infusion of normal saline. The placebo group (P) received normal saline. All patients received 48 h of paracetamol 1 g IV q6h and morphine sulphate 0.1 mg/kg subcutaneous q6h PRN. Morphine consumption, VAS pain scores and occurrence of side effects were recorded for 48 h postoperatively.

resultsPatients in group (Mg + K) (2.4 ± 2.62 mg) and in group (K) (2.8 ± 2.66 mg) had significantly lower morphine consumption in the PACU compared with the patients in group (P) (4.85 ± 4.51 mg) (p = 0.045). Patients in group (Mg + K) consumed significantly less morphine the first 24 postoperative hours, with a relative reduction of 87% and 21% compared with group (K) and group (P) respectively (p = 0.028). However, this difference was not observed at 48 h. No significant difference was shown between the three groups in terms of nausea and vomiting, time to extubation or excessive sedation.

conclusionThe association of magnesium and ketamine bolus followed by infusion in open bariatric surgery appears to be safe and decreases morphine requirements in the first 24 h compared with both ketamine alone and placebo.

Indexed as

Bariatric SurgeryKetamineObesity, MorbidAnalgesicsAnalgesics, OpioidDouble-Blind MethodHumansMagnesiumMorphinePostoperative PainProspective StudiesAnalgesicsAnalgesics, OpioidKetamineMagnesiumMorphineBariatric surgeryKetamineMagnesiumObeseOpioid sparing

Identifiers

PMID31838622
OpenAlexW2996493990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.