Evidence map›Paper›PMID 31838565›Full record

ArticleArchives of toxicology2020

Emerging club drugs: 5-(2-aminopropyl)benzofuran (5-APB) is more toxic than its isomer 6-(2-aminopropyl)benzofuran (6-APB) in hepatocyte cellular models.

Rita Roque Bravo, Helena Carmo, João Pedro Silva, Maria João Valente, Félix Carvalho, Maria de Lourdes Bastos, Diana Dias da Silva

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rita Roque BravoUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. rita.rdsb@gmail.com.ORCID http://orcid.org/0000-0002-2257-6903
Helena CarmoUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.ORCID http://orcid.org/0000-0002-6650-5285
João Pedro SilvaUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.ORCID http://orcid.org/0000-0002-5656-0897
Maria João ValenteUCIBIO, REQUIMTE, Laboratory of Biochemistry, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.ORCID http://orcid.org/0000-0001-6162-2426
Félix CarvalhoUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.ORCID http://orcid.org/0000-0003-3858-3494
Maria de Lourdes BastosUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal.ORCID http://orcid.org/0000-0001-9895-503X
Diana Dias da SilvaUCIBIO, REQUIMTE, Laboratory of Toxicology, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313, Porto, Portugal. up538058@g.uporto.pt.ORCID http://orcid.org/0000-0002-7331-9157
Universidade do Porto · PT

Funding

Applied Molecular Biosciences Unit-UCIBIO UID/Multi/04378/2019Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-029584
6 · The paper itself

Abstract

New phenylethylamine derivatives are among the most commonly abused new psychoactive substances. They are synthesized and marketed in lieu of classical amphetaminic stimulants, with no previous safety testing. Our study aimed to determine the in vitro hepatotoxicity of two benzofurans [6-(2-aminopropyl)benzofuran (6-APB) and 5-(2-aminopropyl)benzofuran (5-APB)] that have been misused as 'legal highs'. Cellular viability was assessed through the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay, following 24-h drug exposure of human hepatoma HepaRG cells (EC

Indexed as

AnimalsAutophagyBenzofuransCells, CulturedChemical and Drug Induced Liver InjuryCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDesigner DrugsHepatocytesHep G2 CellsHumansIsomerismMaleMembrane Potential, MitochondrialOxidative StressPropylamines5-(2-aminopropyl)benzofuran6-(2-aminopropyl)benzofuranBenzofuransCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDesigner DrugsPropylaminesReactive Oxygen SpeciesBenzofuryBioactivationCell deathIn vitroLiverToxicity

Identifiers

PMID31838565
OpenAlexW2996235758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.