SynthesisPediatric surgery international2020
Nonoperative treatment for nonperforated appendicitis in children: a systematic review and meta-analysis.
Synthesis in Pediatric surgery international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Nonoperative Management of Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Comparing Antibiotic Treatment and Appendectomy in Children and Adolescents.World journal of surgery · 2026Pooled it
- Efficacy and Safety of Non-Operative Management of Uncomplicated Acute Appendicitis Compared to Appendectomy: An Umbrella Review of Systematic Reviews and Meta-Analyses.World journal of surgery · 2022Pooled it
- Acute Appendicitis in Childhood and Adulthood.Deutsches Arzteblatt international · 2020Pooled it
- Non-operative versus operative management of uncomplicated acute appendicitis: a randomized controlled study in Sierra Leone.BMC surgery · 2026Trial
- CONservative TReatment of Appendicitis in Children: a randomised controlled feasibility Trial (CONTRACT).Archives of disease in childhood · 2021Trial
- Non-operative Management of Uncomplicated Appendicitis: A Review of Indications, Safety, and Clinical Algorithms.Cureus · 2026Review
- Differentiating Uncomplicated From Complicated Acute Appendicitis in Paediatric Patients With C-Reactive Protein and Imaging Findings-A Retrospective Single Centre Study in 1149 Patients.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Comparison of the Diagnostic Value of the Neutrophil-to-Lymphocyte Ratio Versus the Pediatric Appendicitis Scoring System in Children with Suspected Acute Appendicitis.Bulletin of emergency and trauma · 2026Article
- Article
- Clinical effect of fast-track surgery on laparoscopic treatment of pediatric acute appendicitis and its effect on abdominal inflammation and stress level.Pakistan journal of medical sciences · 2025Article
- Utility of serum and urine leucine-rich alpha-2 glycoprotein 1 (LRG1) as predictors of appendicitis and complicated appendicitis in children.Pediatric surgery international · 2025Article
- Comparative evaluation of ultrasound-guided versus operative drainage for pediatric appendicular abscess: Effectiveness, safety and clinical outcomes.Bioinformation · 2025Article
- Perforated Appendicitis in Children: Management, Microbiology, and Antibiotic Stewardship.Paediatric drugs · 2024Review
- Review
- Associations between Th1-related cytokines and complicated pediatric appendicitis.Scientific reports · 2024Article
- Stumped by a Case of Appendicitis After Appendectomy.Ochsner journal · 2024Article
- Management of pediatric appendicitis during the COVID-19 pandemic: A nationwide multicenter cohort study.Journal of pediatric surgery · 2023Article
- Association of the Bacteria of the Vermiform Appendix and the Peritoneal Cavity with Complicated Acute Appendicitis in Children.Diagnostics (Basel, Switzerland) · 2023Article
- Hyperfibrinogenemia and hyponatremia as predictors of perforated appendicitis in children: A retrospective cohort study.International journal of colorectal disease · 2023Article
- Diagnostic Algorithm Based on Machine Learning to Predict Complicated Appendicitis in Children Using CT, Laboratory, and Clinical Features.Diagnostics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Acute appendicitis is the most common surgical emergency in children. Nonoperative treatment of nonperforated acute appendicitis in children is an alternative to appendectomy. The purpose of this systematic review and meta-analysis was to determine the outcomes of nonoperative treatment of nonperforated acute appendicitis in children in the literature. Databases were searched to identify abstracts, using predefined search terms. The abstracts were reviewed by two independent reviewers and articles were selected according to inclusion and exclusion criteria. Data were extracted by the two reviewers and analyzed. The literature search yielded 2743 abstracts. Twenty-one articles were selected for analysis. The study design was heterogenous, with only one randomized controlled study. The symptoms resolved in 92% [95% CI (88; 96)] of the nonoperatively treated patients. Meta-analysis showed that an additional 16% (95% CI 10; 22) of patients underwent appendectomy after discharge from initial hospital stay. Complications and length of hospital stay was not different among patients treated with antibiotics compared with those who underwent appendectomy. Nonoperative treatment of nonperforated acute appendicitis children is safe and efficient. There is a lack of large randomized controlled trials to compare outcomes of nonoperative treatment with appendectomy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.