ArticleCerebral cortex (New York, N.Y. : 1991)2020
Heritability and Cognitive Relevance of Structural Brain Controllability.
Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Mindful attention promotes control of brain network dynamics for self-regulation and discontinues the past from the present.Proceedings of the National Academy of Sciences of the United States of America · 2023Trial
- Controllability of morphometric network colocalize with underlying neurobiology in major depression.Psychological medicine · 2026Article
- The Neural Association Between Symptom and Cognition in Major Depressive Disorder: A Network Control Theory Study.Human brain mapping · 2025Article
- Network control theory applied to the human connectome: A study on variability and discriminability of fMRI connectomic features under normal and defective sensorineural conditions.Network neuroscience (Cambridge, Mass.) · 2025Article
- Morphological Brain Networks of White Matter: Mapping, Evaluation, Characterization, and Application.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies.Nature biomedical engineering · 2024Article
- Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder.EBioMedicine · 2024Article
- Development of the brain network control theory and its implications.Psychoradiology · 2024Review
- Higher general intelligence is associated with stable, efficient, and typical dynamic functional brain connectivity patterns.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Controlling target brain regions by optimal selection of input nodes.PLoS computational biology · 2024Article
- Modelling and Controlling System Dynamics of the Brain: An Intersection of Machine Learning and Control Theory.Advances in neurobiology · 2024Review
- Network controllability of structural connectomes in the neonatal brain.Nature communications · 2023Article
- Alprazolam modulates persistence energy during emotion processing in first-degree relatives of individuals with schizophrenia: a network control study.Molecular psychiatry · 2023Article
- Transitions between cognitive topographies: contributions of network structure, neuromodulation, and disease.bioRxiv : the preprint server for biology · 2023Article
- Genetic, individual, and familial risk correlates of brain network controllability in major depressive disorder.Molecular psychiatry · 2023Article
- Article
- The expanding horizons of network neuroscience: From description to prediction and control.NeuroImage · 2022Review
- Alterations in white matter network dynamics in patients with schizophrenia and bipolar disorder.Human brain mapping · 2022Article
- Dynamic trajectories of connectome state transitions are heritable.NeuroImage · 2022Article
- Control theory illustrates the energy efficiency in the dynamic reconfiguration of functional connectivity.Communications biology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Cognition and behavior are thought to emerge from the connections and interactions among brain regions. The precise nature of these relationships remains elusive. Here we use tools provided by network control theory to determine how the structural connectivity profile of brain regions may shape individual variation in cognition. In a cohort of healthy young adults (n = 1066), we computed two fundamental brain regional control patterns, average and modal controllability, which index the degree of influence of a region over others. We first established that regional brain controllability measures were both reproducible and heritable. Regions with controllability profiles theoretically conducive to facilitating multiple cognitive operations were over-represented in higher-order resting-state networks. Finally, variation in regional controllability accounted for about 50% of interindividual variability in multiple cognitive domains. We conclude that controllability is a biologically plausible property of the structural connectome and provides a mechanistic explanation for how brain structural architecture may influence cognitive functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.