Evidence map›Paper›PMID 31838127›Full record

ArticleThe Journal of investigative dermatology2020

Utilizing Machine Learning for Image Quality Assessment for Reflectance Confocal Microscopy.

Kivanc Kose, Alican Bozkurt, Christi Alessi-Fox, Dana H Brooks, Jennifer G Dy, Milind Rajadhyaksha, Melissa Gill

Abstract readMulticenter Study
In one paragraph

Article in The Journal of investigative dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Utilizing deep learning for dermal matrix quality assessment on in vivo line-field confocal optical coherence tomography images.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Article
  5. MxIF Q-score: Biology-Informed Quality Assurance for Multiplexed Immunofluorescence Imaging.Medical optical imaging and virtual microscopy image analysis : first International Workshop, MOVI 2022, held in conjunction with MICCAI 2022, Singapore, September 18, 2022, Proceedings. MOVI (Workshop) (1st : 2022 : Singapore) · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Deep Learning in Biomedical Optics.Lasers in surgery and medicine · 2021
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kivanc KoseDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address: kosek@mskcc.org.
Alican BozkurtElectrical and Computer Engineering, Northeastern University, Boston, Massachusetts, USA.
Christi Alessi-FoxCaliber Imaging and Diagnostics, Inc, Rochester, New York, USA.
Dana H BrooksElectrical and Computer Engineering, Northeastern University, Boston, Massachusetts, USA.
Jennifer G DyElectrical and Computer Engineering, Northeastern University, Boston, Massachusetts, USA.
Milind RajadhyakshaDermatology Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Melissa GillDepartment of Pathology, SUNY Downstate Medical Center, Brooklyn, New York, USA; SkinMedical Research and Diagnostics, PLLC, Dobbs Ferry, New York, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Automated Image Guidance for Diagnosing Skin Cancer With Confocal MicroscopyR01CA199673 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI DY, JENNIFER G, RAJADHYAKSHA, MILIND · 2015 to 2018
$2.5M
CONFOCAL IMAGING THROUGH THICK DERMAL TISSUE (PHASE II)R44CA058054 · NCI · LUCID TECHNOLOGIES, INC. · PI EASTMAN, JAY M. · 1995 to 2008
$2.0M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA199673NCI NIH HHS R44 CA058054
6 · The paper itself

Abstract

In vivo reflectance confocal microscopy (RCM) enables clinicians to examine lesions' morphological and cytological information in epidermal and dermal layers while reducing the need for biopsies. As RCM is being adopted more widely, the workflow is expanding from real-time diagnosis at the bedside to include a capture, store, and forward model with image interpretation and diagnosis occurring offsite, similar to radiology. As the patient may no longer be present at the time of image interpretation, quality assurance is key during image acquisition. Herein, we introduce a quality assurance process by means of automatically quantifying diagnostically uninformative areas within the lesional area by using RCM and coregistered dermoscopy images together. We trained and validated a pixel-level segmentation model on 117 RCM mosaics collected by international collaborators. The model delineates diagnostically uninformative areas with 82% sensitivity and 93% specificity. We further tested the model on a separate set of 372 coregistered RCM-dermoscopic image pairs and illustrate how the results of the RCM-only model can be improved via a multimodal (RCM + dermoscopy) approach, which can help quantify the uninformative regions within the lesional area. Our data suggest that machine learning-based automatic quantification offers a feasible objective quality control measure for RCM imaging.

Indexed as

Machine LearningDermoscopyDiagnosis, DifferentialFeasibility StudiesHumansImage Processing, Computer-AssistedMicroscopy, ConfocalQuality ControlSkinSkin Diseases

Identifiers

PMID31838127
PMCPMC7967900

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.