Evidence map›Paper›PMID 31838024›Full record

ReviewNeurochemistry international2020

Epigenetic mechanisms of neurodegenerative diseases and acute brain injury.

Mario J Bertogliat, Kahlilia C Morris-Blanco, Raghu Vemuganti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurochemistry international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mario J BertogliatDepartment of Neurological Surgery, University of Wisconsin, Madison, WI, USA.
Kahlilia C Morris-BlancoDepartment of Neurological Surgery, University of Wisconsin, Madison, WI, USA; William S. Middleton VA Hospital, Madison, WI, USA.
Raghu VemugantiDepartment of Neurological Surgery, University of Wisconsin, Madison, WI, USA; William S. Middleton VA Hospital, Madison, WI, USA. Electronic address: vemuganti@neurosurgery.wisc.edu.

Funding

DNA hydroxymethylation and post stroke brain damageR01NS109459 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2018 to 2022
$2.1M
Therapeutic Targeting of an lncRNA in Experimental Stroke Using STAIR CriteriaR01NS099531 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2017 to 2021
$2.0M
Targeting alpha-synuclein after cerebral ischemia as a function of sex and ageR01NS101960 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2017 to 2021
$1.6M
LncRNA FosDT mediates ischemic brain damageR21NS095192 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2015 to 2016
$558k
BLRD VA I01 BX004344NINDS NIH HHS R01 NS099531NINDS NIH HHS R01 NS101960NINDS NIH HHS R01 NS109459NINDS NIH HHS R21 NS095192
6 · The paper itself

Abstract

Epigenetic modifications are emerging as major players in the pathogenesis of neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone modifications act together with non-coding RNAs to form a complex gene expression machinery that adapts the brain to environmental stressors and injury response. These modifications influence cell-level operations like neurogenesis and DNA repair to large, intricate processes such as brain patterning, memory formation, motor function and cognition. Thus, epigenetic imbalance has been shown to influence the progression of many neurological disorders independent of aberrations in the genetic code. This review aims to highlight ways in which epigenetics applies to several commonly researched neurodegenerative diseases and forms of acute brain injury as well as shed light on the benefits of epigenetics-based treatments.

Indexed as

AgingAnimalsBrainBrain InjuriesEpigenesis, GeneticGene ExpressionHumansNeurodegenerative DiseasesNeurogenesisAlzheimer's diseaseCerebral ischemiaEpilepsyHuntington's diseaseParkinson's diseaseStrokeTraumatic brain injury

Identifiers

PMID31838024
PMCPMC8074401

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.