ArticleCortex; a journal devoted to the study of the nervous system and behavior2020
Amount and delay insensitivity during intertemporal choice in three neurodegenerative diseases reflects dorsomedial prefrontal atrophy.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Aberrant Medial Prefrontal Cortex Activity and Flexible Behavior in the TgF344-AD Rat Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Mapping the brain atrophy mediating increased impatience for reward in frontotemporal dementia.Communications biology · 2026Article
- Subjective time perception in dementia: a behavioural and neuroanatomical analysis.Brain communications · 2026Article
- Prevalence of hearing loss in patients with dementia and its association with dementia severity.SAGE open medicine · 2025Article
- A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls.bioRxiv : the preprint server for biology · 2024Article
- In a circuit necessary for cognition and emotional affect, Alzheimer's-like pathology associates with neuroinflammation, cognitive and motivational deficits in the young adult TgF344-AD rat.Brain, behavior, & immunity - health · 2024Article
- The guaranteed euros: Probabilistic discounting in behavioural-variant frontotemporal dementia.Journal of neuropsychology · 2024Article
- Real World Financial Mismanagement in Alzheimer's Disease, Frontotemporal Dementia, and Primary Progressive Aphasia.Journal of Alzheimer's disease : JAD · 2024Article
- Reward processing deficits arise early in familial frontotemporal dementia.Frontiers in neuroscience · 2024Article
- Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient.Frontiers in neurology · 2023Article
- Human microRNA-4433 (hsa-miR-4443) Targets 18 Genes to be a Risk Factor of Neurodegenerative Diseases.Current Alzheimer research · 2022Article
- Subjective Time in Dementia: A Critical Review.Brain sciences · 2021Review
- Neural representations of the amount and the delay time of reward in intertemporal decision making.Human brain mapping · 2021Article
- Salience driven attention is pivotal to understanding others' intentions.Cognitive neuropsychology · 2021Article
- Decision-Making Support for People With Alzheimer's Disease: A Narrative Review.Frontiers in psychology · 2021Review
- Interactions between decision-making and emotion in behavioral-variant frontotemporal dementia and Alzheimer's disease.Social cognitive and affective neuroscience · 2020Article
- Links between autobiographical memory richness and temporal discounting in older adults.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Patients with Alzheimer's disease and other dementias often make poor financial decisions, but it remains unclear whether this reflects specific failures in decision-making or more general deficits in episodic and working memory. We investigated how patients with Alzheimer's disease, behavioral variant frontotemporal dementia (bvFTD), and semantic variant primary progressive aphasia (svPPA) apply information in an intertemporal choice task between smaller intermediate and larger delayed rewards, with minimal memory demands. Multilevel modeling estimated subject-level sensitivities to three attributes of choice (the relative difference in reward magnitude, delay length, and absolute reward magnitudes) as well as baseline impulsivity. While baseline impulsivity in patients with Alzheimer's disease did not differ from controls, patients with bvFTD and svPPA were more impulsive than controls overall. Patients with Alzheimer's disease or bvFTD were less sensitive than controls to all three choice attributes, whereas patients with svPPA were less sensitive than controls to two attributes. Attenuated sensitivity to information presented during the choice was associated across all subjects with dorsomedial prefrontal atrophy for all three choice attributes. Given the minimal memory demands of our task, these findings suggest specific mechanisms underlying decision-making failures beyond episodic and working memory deficits in dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.