ReviewSurvey of ophthalmology
Primary ductal adenocarcinoma of the lacrimal gland: A review and report of five cases.
Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Imaging features of lacrimal gland disease.Frontiers in ophthalmology · 2025Review
- The poor prognosis of lacrimal gland adenocarcinoma: a clinical study and literature review.Journal of cancer research and clinical oncology · 2024Review
- Primary Ductal Her-2 Positive Adenocarcinoma of Salivary Gland: A Long Follow-Up Case Report and Review of the Literature.Case reports in ophthalmological medicine · 2024Article
- The 5th Edition of the World Health Organization Classification of Tumours of the Eye and Orbit.Ocular oncology and pathology · 2023Article
- Malignant neoplasm of lacrimal gland with pulmonary metastasis.Respirology case reports · 2023Article
- Androgen receptor increases and negative expression of GCDFP-15 in primary ductal adenocarcinoma of the lacrimal gland: a case description.Quantitative imaging in medicine and surgery · 2023Article
- Clinico-epidemiological analysis of 1000 cases of orbital tumors.Japanese journal of ophthalmology · 2021Article
- Rare Diseases of the Orbit.Laryngo- rhino- otologie · 2021Review
- Hybrid neoplasm of the lacrimal gland, adenocarcinoma NOS with primary squamous cell carcinoma; A rare case report.Journal of oral biology and craniofacial researchArticle
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
Primary ductal adenocarcinoma (PDA) is a rare epithelial tumor of the lacrimal gland. Herein we report 5 cases and review 29 published cases of PDA of the lacrimal gland. Among these 5 cases, the most common clinical presentation was painless swelling and/or proptosis of their eye. The size of the lesions ranged from 1.6 to 2.5 cm. Histopathologic examination revealed proliferations of ductal or gland-like cells with vesiculated pleomorphic nuclei and prominent nucleoli. Tumor cells stained positive for epithelial and apocrine differentiation markers. Immunohistochemistry for human epidermal growth factor 2 was positive in 2 of the 4 cases. Four of the five patients were alive at the last follow-up visit. One died with bone metastases, which were diagnosed 25 months after exenteration and then survived an additional 51 months. On reviewing of twenty-nine previously published cases of PDA, the mean age of diagnosis was 58 years, with a male predominance (75%). Fifteen patients (54%) had distant metastases, 1 (4%) had local recurrence, and 10 (37%) suffered from a PDA-related death. PDA is a high-grade aggressive epithelial tumor of the lacrimal gland. Although rare, awareness and recognition of this malignancy are important to help determine prognosis and treatment options.
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