Evidence map›Paper›PMID 31837130›Full record

ArticleThe American journal of tropical medicine and hygiene2020

Nontraumatic Myelopathy in Malawi: A Prospective Study in an Area with High HIV Prevalence.

Eduard E Zijlstra, Jaap J van Hellemond, Arthur D Moes, Christa de Boer, Shelley A Boeschoten, Catharina E M van Blijswijk, Roos M van der Vuurst de Vries, Peter A B Bailey, Sam Kampondeni, Lisette van Lieshout and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Neuromyelitis Optica Spectrum Disorders in Africa: A Systematic Review.Neurology(R) neuroimmunology & neuroinflammation · 2021
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Eduard E ZijlstraDepartment of Medicine, College of Medicine, Blantyre, Malawi.
Jaap J van HellemondDepartment of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, The Netherlands.
Arthur D MoesDivision of Nephrology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Christa de BoerInfectious Disease Control, Municipal Health Service Zuid-Holland Zuid, Dordrecht, The Netherlands.
Shelley A BoeschotenErasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.
Catharina E M van BlijswijkVrije Universiteit Medisch Centrum (VUMC), Amsterdam, The Netherlands.
Roos M van der Vuurst de VriesDepartment of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Peter A B BaileyGold Coast University Hospital, Southport, Australia.
Sam KampondeniSam Kampondeni Clinic, Blantyre, Malawi.
Lisette van LieshoutDepartment of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands.
Saskia L SmitsViroclinics Biosciences BV, Rotterdam Science Tower, Rotterdam, The Netherlands.
Juri KatchanovDepartment of Hematology and Oncology, LMU University of Munich, Munich, Germany.
Nyengo M MkandawireDepartment of Surgery, College of Medicine, Blantyre, Malawi.
Camilla RotheDivision of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, Munich, Germany.
Erasmus MC · NLBlantyre Institute for Community Ophthalmology · MWGGD Zuid Limburg · NLGold Coast Hospital · AULeiden University Medical Center · NLLudwig-Maximilians-Universität München · DEUniversity of Malawi · MWViroclinics Biosciences (Netherlands) · NLVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nontraumatic myelopathy causes severe morbidity and is not uncommon in Africa. Clinically, patients often present with paraplegia, and extrinsic cord compression and transverse myelitis are most common causes. Data on exact pathogenesis are scanty because of limitations in diagnostic methods. In Queen Elizabeth Central Hospital, Blantyre, Malawi, we recorded consecutive patients presenting with nontraumatic paraplegia for maximally 6 months between January and July 2010 and from March to December 2011. The diagnostic workup included imaging and examining blood, stool, urine, sputum, and cerebrospinal fluid (CSF) samples for infection. After discharge, additional diagnostic tests, including screening for virus infections, borreliosis, syphilis, and schistosomiasis, were carried out in the Netherlands. The clinical diagnosis was, thus, revised in retrospect with a more accurate final differential diagnosis. Of 58 patients included, the mean age was 41 years (range, 12-83 years) and the median time between onset and presentation was 18 days (range, 0-121 days), and of 55 patients tested, 23 (42%) were HIV positive. Spinal tuberculosis (

Indexed as

AdolescentAdultAgedAged, 80 and overChildFemaleHIV AntibodiesHIV InfectionsHumansMalawiMaleMiddle AgedPrevalenceProspective StudiesSpinal Cord DiseasesYoung AdultHIV Antibodies

Identifiers

PMID31837130
PMCPMC7008330
OpenAlexW2994849985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.