Evidence map›Paper›PMID 31837128›Full record

ArticleJournal of biomedical optics2019

Super-resolution recurrent convolutional neural networks for learning with multi-resolution whole slide images.

Lopamudra Mukherjee, Huu Dat Bui, Adib Keikhosravi, Agnes Loeffler, Kevin Eliceiri

Abstract read
In one paragraph

Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lopamudra MukherjeeUniv. of Wisconsin-Whitewater, United States.
Huu Dat BuiUniv. of Wisconsin-Whitewater, United States.
Adib KeikhosraviUniv. of Wisconsin-Madison, United States.
Agnes LoefflerMetroHealth Medical Ctr., United States.
Kevin EliceiriUniv. of Wisconsin-Madison, United States.

Funding

Collagen structural changes as an early biomarker for breast carcinomaR01CA199996 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CONKLIN, MATTHEW W · 2015 to 2019
$2.2M
NCI NIH HHS R01 CA199996
6 · The paper itself

Abstract

We study a problem scenario of super-resolution (SR) algorithms in the context of whole slide imaging (WSI), a popular imaging modality in digital pathology. Instead of just one pair of high- and low-resolution images, which is typically the setup in which SR algorithms are designed, we are given multiple intermediate resolutions of the same image as well. The question remains how to best utilize such data to make the transformation learning problem inherent to SR more tractable and address the unique challenges that arises in this biomedical application. We propose a recurrent convolutional neural network model, to generate SR images from such multi-resolution WSI datasets. Specifically, we show that having such intermediate resolutions is highly effective in making the learning problem easily trainable and address large resolution difference in the low and high-resolution images common in WSI, even without the availability of a large size training data. Experimental results show state-of-the-art performance on three WSI histopathology cancer datasets, across a number of metrics.

Indexed as

Neural Networks, ComputerAlgorithmsHistological TechniquesHumansImage Interpretation, Computer-AssistedMachine LearningMicroscopyNeoplasmsconvolutional neural networksimage super-resolutionmachine learningpathologywhole slide imaging

Identifiers

PMID31837128
PMCPMC6910074

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.