ArticleJournal of clinical laboratory analysis2020
Association between obesity categories with cardiovascular disease and its related risk factors in the MASHAD cohort study population.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 17 citations in OpenAlex.
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- Association of Serum Lipids with 10-Year CVD and All-Cause Mortality in Iranian Adults: A Prospective Cohort Study.Archives of Iranian medicine · 2025Article
- Impact of BMI Reduction After Sleeve Surgery on ESR and CRP Levels in Patients with Obesity.Obesity surgery · 2025Observational
- Beyond traditional metrics: evaluating the triglyceride-total cholesterol-body weight index (TCBI) in cardiovascular risk assessment.BMC cardiovascular disorders · 2025Article
- Exploring the Influence of BMI on Gait Metrics: A Comprehensive Analysis of Spatiotemporal Parameters and Stability Indicators.Sensors (Basel, Switzerland) · 2024Observational
- The associations of oxidative stress and inflammatory markers with obesity in Iranian population: MASHAD cohort study.BMC endocrine disorders · 2024Article
- Micronutrients intake and genetic variants associated with premature ovarian insufficiency; MASHAD cohort study.BMC women's health · 2024Article
- Predicting the Length of Stay of Cardiac Patients Based on Pre-Operative Variables-Bayesian Models vs. Machine Learning Models.Healthcare (Basel, Switzerland) · 2024Article
- The association of Carbohydrate Quality Index with cardiovascular disease risk factors among women with overweight and obesity: A cross-sectional study.Frontiers in nutrition · 2022Article
- Association between obesity categories with cardiovascular disease and its related risk factors in the MASHAD cohort study population.Journal of clinical laboratory analysis · 2020Article
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18 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundCardiovascular disease (CVD) is a significant cause of morbidity and mortality globally. Obesity is an important CVD risk factor and is increasing in prevalence.
methodsIn this study, 3829 men and 5720 women (35-65 years) were enrolled as part of the MASHAD cohort study. Four categories were identified according to body mass index and waist circumference that was defined by the World Health Organization. Logistic regression analysis was used to determine the adjusted odds ratio (OR) for the occurrence of CVD, and Cox regression model was used to evaluate the association of obesity with CVD incidence.
resultsWe found that the higher risk groups defined by categories of adiposity were significantly related to a higher prevalence of a high serum total cholesterol (TC), and triglycerides (TG), and lower high-density lipoprotein cholesterol (HDL), and higher fasting blood glucose (FBG) in both genders and a higher low-density lipoprotein cholesterol (LDL) in women (P < .001). Additionally, a high percentage of participants with dyslipidemia, high LDL, high TC, and low HDL and a high percentage of participants with metabolic syndrome, diabetes, hypertension, and a high serum TG were observed across obesity categories (P < .001). Moreover, women with the very high degrees of obesity had a greater risk of CVD (HR: 1.91, 95% CI: 1.06-3.43, P = .03).
conclusionObesity strongly predicts several CVD risk factors. Following 6 years of follow-up, in individuals within increasing degrees of obesity, there was a corresponding significant increase in CVD events, rising to approximately a twofold higher risk of cardiovascular events in women compared with men.
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