ArticleHuman psychopharmacology2019
Driving performance and neurocognitive skills of long-term users of benzodiazepine anxiolytics and hypnotics.
Article in Human psychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Driving Performance Under Treatment of Most Frequently Prescribed Drugs for Mental Disorders: A Systematic Review of Patient Studies.The international journal of neuropsychopharmacology · 2021Pooled it
- Effect of a Single Oral Dose of Dexamphetamine or Zolpidem on Attention and Reaction Time in Healthy Men.Fundamental & clinical pharmacology · 2026Trial
- Acute administration of alprazolam, alcohol and their combination on cognitive performance and mood: A randomised, double-blind, placebo-controlled study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Driving Performance after Bedtime Administration of Daridorexant, Assessed in a Sensitive Simulator.Clinical pharmacology and therapeutics · 2022Trial
- Antidepressants and Road Safety: A Forensic Toxicological Perspective Based on Observational Data and Current Evidence.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Nonbenzodiazepine hypnotics and police-reported motor vehicle crash risk among older adults: a sequential target trial emulation.American journal of epidemiology · 2025Article
- A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.Exploratory research in clinical and social pharmacy · 2024Article
- Driving anxiety and anxiolytics while driving: Their impacts on behaviour and cognition behind the wheel.Heliyon · 2023Review
- Interpol review of toxicology 2019-2022.Forensic science international. Synergy · 2023Review
- Benzodiazepines in sport, an underestimated problem: Recommendations for sports medicine physicians' practice.Frontiers in psychiatry · 2022Article
- Guiding principles for determining work shift duration and addressing the effects of work shift duration on performance, safety, and health: guidance from the American Academy of Sleep Medicine and the Sleep Research Society.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- An explorative approach to understanding individual differences in driving performance and neurocognition in long-term benzodiazepine users.Human psychopharmacology · 2021Article
- Driving performance and neurocognitive skills of long-term users of sedating antidepressants.Human psychopharmacology · 2021Article
- Driving performance and neurocognitive skills of long-term users of benzodiazepine anxiolytics and hypnotics.Human psychopharmacology · 2019Article
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Authors and funding
9 authors.
Funding
Abstract
objectiveThe aim of this study is to compare actual driving performance and skills related to driving of patients using benzodiazepine anxiolytics or hypnotics for at least 6 months to that of healthy controls.
methodsParticipants were 44 long-term users of benzodiazepine and benzodiazepine-related anxiolytics (n = 12) and hypnotics (n = 32) and 65 matched healthy controls. Performance was assessed using an on-the-road driving test measuring standard deviation of lateral position (SDLP, in cm) and a battery of neurocognitive tasks. Performance differences between groups were compared with a blood alcohol concentration of 0.5 mg/ml to determine clinical relevance.
resultsCompared with controls, SDLP was significantly increased in hypnotic users (+1.70 cm) but not in anxiolytic users (+1.48 cm). Anxiolytic and hypnotic users showed significant and clinically relevant impairment on neurocognitive task measuring executive functioning, vigilance, and reaction time. For patients using hypnotics for at least 3 years, no significant driving impairment was observed.
conclusionImpairing effects of benzodiazepine hypnotics on driving performance may mitigate over time following longer term use (i.e. 3 years or more) although neurocognitive impairments may remain.
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