Evidence map›Paper›PMID 31836852›Full record

ArticleLeukemia2020

SHP1 regulates a STAT6-ITGB3 axis in FLT3ITD-positive AML cells.

Daniela Reich, Anne Kresinsky, Jörg P Müller, Reinhard Bauer, Julia Kallenbach, Tina M Schnoeder, Florian H Heidel, Reinhard Fässler, Matthias Mann, Frank-D Böhmer and 1 more

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Strategy for Leukemia Treatment Targeting SHP-1,2 and SHIP.Frontiers in cell and developmental biology · 2021
    Review
  6. Identification and Validation ofOncoTargets and therapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniela Reich *Institute of Molecular Cell Biology, CMB, Jena University Hospital, Jena, Germany.
Anne KresinskyInstitute of Molecular Cell Biology, CMB, Jena University Hospital, Jena, Germany.
Jörg P MüllerInstitute of Molecular Cell Biology, CMB, Jena University Hospital, Jena, Germany.
Reinhard BauerInstitute of Molecular Cell Biology, CMB, Jena University Hospital, Jena, Germany.
Julia KallenbachInstitute of Molecular Cell Biology, CMB, Jena University Hospital, Jena, Germany.
Tina M SchnoederLeibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
Florian H HeidelLeibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
Reinhard FässlerDepartment of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany.
Matthias MannDepartment of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. mmann@biochem.mpg.de.
Frank-D BöhmerInstitute of Molecular Cell Biology, CMB, Jena University Hospital, Jena, Germany. boehmer@med.uni-jena.de.
Ashok Kumar Jayavelu *Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany. jayavelu@biochem.mpg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, LeukemicAnimalsApoptosisCell Proliferationfms-Like Tyrosine Kinase 3HumansIntegrin beta3Leukemia, Myeloid, AcuteMiceMice, Inbred C3HProtein Tyrosine Phosphatase, Non-Receptor Type 6Repetitive Sequences, Nucleic AcidSTAT6 Transcription FactorTumor Cells, CulturedXenograft Model Antitumor AssaysFLT3 protein, humanfms-Like Tyrosine Kinase 3Integrin beta3ITGB3 protein, humanProtein Tyrosine Phosphatase, Non-Receptor Type 6PTPN6 protein, humanSTAT6 protein, humanSTAT6 Transcription Factor

Identifiers

PMID31836852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.