ArticleScientific reports2019
Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations.
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Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Review of the clinical electrooculogram - Part 2: the bestrophinopathies and modified protocols.Documenta ophthalmologica. Advances in ophthalmology · 2026Review
- Allele-specific suppression of pathogenic bestrophin-1 transcripts by CRISPR/Cas9-mediated genome editing.Genome medicine · 2026Article
- From BEST1 mutations to retinal regeneration: integrating stem cell-derived RPE models and gene correction strategies.Frontiers in cell and developmental biology · 2026Review
- Gene Therapy Strategies for the Treatment of Bestrophinopathies.International journal of molecular sciences · 2025Review
- Divergent Manifestations in Biallelic Versus Monoallelic Variants of RP1-, BEST1-, and PROM1-Associated Retinal Disorders.International journal of molecular sciences · 2025Article
- Clinical and Genetic Features of Autosomal Recessive Bestrophinopathy: A Case Series from a Vietnamese Cohort.Biomedicines · 2025Article
- Neurotransmitter-bound bestrophin channel structures reveal small molecule drug targeting sites for disease treatment.Nature communications · 2024Article
- Article
- Ion channels research in hPSC-RPE cells: bridging benchwork to clinical applications.Journal of translational medicine · 2024Review
- GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel.Nature communications · 2024Article
- Evaluating precision medicine approaches for gene therapy in patient-specific cellular models of Bietti crystalline dystrophy.JCI insight · 2024Article
- Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases.Stem cell research & therapy · 2023Review
- TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status.Antioxidants (Basel, Switzerland) · 2023Article
- Photoreceptor Function and Structure in Autosomal Dominant Vitelliform Macular Dystrophy Caused by BEST1 Mutations.Investigative ophthalmology & visual science · 2022Article
- Article
- Heterogeneity of Potassium Channels in Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium.Stem cells translational medicine · 2022Article
- Structures and gating mechanisms of human bestrophin anion channels.Nature communications · 2022Article
- Impaired Bestrophin Channel Activity in an iPSC-RPE Model of Best Vitelliform Macular Dystrophy (BVMD) from an Early Onset Patient Carrying the P77S Dominant Mutation.International journal of molecular sciences · 2022Article
- Clinical and visual electrophysiological characteristics of vitelliform macular dystrophies in the first decade of life.Indian journal of ophthalmology · 2022Article
- Oncogenic potential of BEST4 in colorectal cancer via activation of PI3K/Akt signaling.Oncogene · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Changyi JiDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Yao LiDepartment of Ophthalmology, Columbia University, New York, NY, 10032, USA.
Alec KittredgeDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Austin HopiavuoriDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Nancy WardDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA.
Peng YaoAab Cardiovascular Research Institute, Department of Medicine, University of Rochester, School of Medicine & Dentistry, Rochester, NY, 14586, USA.
Yohta FukudaDivision of Advance Pharmaco-Science, Graduate School of Pharmaceutical Science, Osaka University, Yamadaoka 1-6, Suita, Osaka, 565-0871, Japan.
Yu ZhangDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA. yz3802@cumc.columbia.edu.
Stephen H TsangJonas Children's Vision Care, and Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology and Pathology & Cell Biology, Edward S. Harkness Eye Institute, Columbia Stem Cell Initiative, New York Presbyterian Hospital/Columbia University, New York, NY, 10032, USA. sht2@cumc.columbia.edu.
Tingting YangDepartment of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, Rochester, NY, 14642, USA. ty2190@cumc.columbia.edu.
University of Rochester · USColumbia University · USNewYork–Presbyterian Hospital · USOsaka University · JP
Funding
Mechanistic Characterization of Calcium-Activated Chloride Channels in Retinal Pigment EpitheliumR01GM127652 · NIGMS · UNIVERSITY OF ROCHESTER · PI YANG, TINGTING · 2018 to 2022
$1.7MRole of miR-574-Fam210a axis in cardiac hypertrophy and remodelingR01HL132899 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAO, PENG · 2018 to 2021
$1.5MTranslational Control of Cardiac FibrosisR01HL147954 · NHLBI · UNIVERSITY OF ROCHESTER · PI YAO, PENG · 2019 to 2022
$1.5MStructure-function Analysis of BestrophinsR00EY025290 · NEI · UNIVERSITY OF ROCHESTER · PI YANG, TINGTING · 2016 to 2018
$747kStructure-function Analysis of BestrophinsK99EY025290 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YANG, TINGTING · 2015 to 2015
$106kNEI NIH HHS R00 EY025290NHLBI NIH HHS R01 HL132899NHLBI NIH HHS R01 HL147954NIGMS NIH HHS R01 GM127652
Abstract
BEST1 is a Ca
Indexed as
Genes, DominantAdultBestrophinsChildFemaleHumansMaleMiddle AgedMutationPhenotypeRetinal Pigment EpitheliumVitelliform Macular DystrophyYoung AdultBEST1 protein, humanBestrophins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.