Evidence map›Paper›PMID 31836735›Full record

ArticleScientific reports2019

High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana.

Isabella Quakyi, Bernard Tornyigah, Pascal Houze, Kwadwo A Kusi, Nathaniel Coleman, Guillaume Escriou, Amos Laar, Michel Cot, Julius Fobil, Gloria Quansah Asare and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
37.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 182 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Isabella QuakyiUniversité de Paris, MERIT, IRD, F-75006, Paris, France.
Bernard TornyigahUniversité de Paris, MERIT, IRD, F-75006, Paris, France.
Pascal HouzeService de biochimie générale, Hôpital universitaire Necker-Enfants Malades, AP-HP, 149 rue de Sèvres, 75015, Paris, France.
Kwadwo A KusiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, Legon, Ghana.ORCID http://orcid.org/0000-0001-5483-9985
Nathaniel ColemanDepartment of Biological Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.
Guillaume EscriouUniversité de Paris, MERIT, IRD, F-75006, Paris, France.
Amos LaarDepartment of Biological Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.
Michel CotUniversité de Paris, MERIT, IRD, F-75006, Paris, France.ORCID http://orcid.org/0000-0003-3014-4294
Julius FobilDepartment of Biological Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.
Gloria Quansah AsareDepartment of Biological Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, Legon, Ghana.
Philippe DeloronUniversité de Paris, MERIT, IRD, F-75006, Paris, France.ORCID http://orcid.org/0000-0003-4705-2484
Abraham K AnangDepartment of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Legon, Ghana.
Gilles CottrellUniversité de Paris, MERIT, IRD, F-75006, Paris, France.
Michael F OforiDepartment of Immunology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, Legon, Ghana.
Nicaise Tuikue NdamUniversité de Paris, MERIT, IRD, F-75006, Paris, France. nicaise.ndam@ird.fr.
University of Ghana · GHUniversité Paris Cité · FRNoguchi Memorial Institute for Medical Research · GHHôpital Necker-Enfants Malades · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the clinically proven advantages of intermittent preventive treatment of malaria in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP), utilisation has been low in many African countries. To increase uptake and achieve the desired effect, the World Health Organization revised the policy to a monthly administration. Assessing the coverage and impact of the revised policy on pregnancy and neonatal outcomes is, therefore, a necessity. A 2-parallel cross-sectional hospital-based study was carried out among pregnant women attending first antenatal care (ANC) and delivery. Maternal and cord blood samples were assayed for malaria parasites by quantitative PCR targeting both the 18S rDNA and the acidic terminal segment of Plasmodium falciparum var genes, and plasma SP levels were measured by liquid chromatography coupled to tandem mass spectrometry. Parasite prevalence was similar between the two study sites but decreased significantly between the first ANC (9% or 43%) and delivery (4% or 11%) based on the qPCR target. At delivery, 64.5% of women received ≥3 IPTp-SP dose, 15.5% received 2 doses and 6% had 1 dose. Taking ≥3 IPTp-SP doses was associated with an average birth weight increase of more than 0.165 kg. IPTp-SP uptake was associated with plasma SP level at delivery (OR = 32.3, p ≤ 0.005, 95% CI (13.3;78.4) for those that reported ≥3 IPTp-SP doses) while the same trend of improved birth weight was observed with high plasma SP levels. The new IPTp policy is well implemented and well utilised by women in the sites considered in this study and translates to the improved birth weight observed. This study confirms the interest and the clinical benefit expected from this policy change.

Indexed as

AdolescentAdultBirth WeightCohort StudiesDrug CombinationsFemaleGhanaHumansLinear ModelsMalariaMiddle AgedMultivariate AnalysisPlasmodium falciparumPregnancyPregnancy Complications, ParasiticPrevalenceDrug Combinationsfanasil, pyrimethamine drug combinationPyrimethamineSulfadoxine

Identifiers

PMID31836735
PMCPMC6911095
OpenAlexW2995003707

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.