ArticleScientific reports2019
Oral Microbiota Development in Early Childhood.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Development of 24-Hour Rhythms in Cortisol Secretion Across Infancy: A Systematic Review and Meta-Analysis of Individual Participant Data.The Journal of clinical endocrinology and metabolism · 2025Pooled it
- Oral microbiome diversity and composition before and after chemotherapy treatment in pediatric oncology patients.BMC oral health · 2025Trial
- Effects of oropharyngeal administration of own mother's milk on oral microbial colonization in very low birth weight infants fed by gastric tube: A randomized controlled trial.Immunity, inflammation and disease · 2024Trial
- Longitudinal Follow-Up of Gut and Salivary Microbiota in Children With Food Protein-Induced Enterocolitis Syndrome.Allergy · 2026Article
- A dual-marker approach for forensic age prediction: integrating the salivary microbiome and antibiotic resistome.International journal of legal medicine · 2026Article
- The Oral-Gut-Brain Axis in Pediatric Populations: The Implications of Oral Dysbiosis for Systemic Inflammation and Neuroinflammation.Nutrients · 2026Review
- Targeted next-generation sequencing for pediatric community-acquired pneumonia pathogen detection: a single-center study.Frontiers in cellular and infection microbiology · 2026Article
- Harmonized multi-cohort analysis of oral microbiome development during early lifetime.Journal of oral microbiology · 2026Article
- Signatures of the maternal-infant oral microbiome in contexts of imprisonment and social vulnerability.Frontiers in dental medicine · 2026Article
- The microbiome and non-occupational human-animal interactions: a scoping review.Frontiers in public health · 2026Article
- Development of the Breastfed Infant Oral Microbiome Is Associated with Concentrations and Intakes of Human Milk Oligosaccharides.Nutrients · 2025Article
- The Infant Oral Microbiome: Developmental Dynamics, Modulating Factors, and Implications for Oral and Systemic Health.International journal of molecular sciences · 2025Review
- Modifiable early life risk factors for dental calculus in dogs: a retrospective cross-sectional study in Finland.BMC veterinary research · 2025Article
- The oral microbiome in aging: a window into health and longevity.Journal of oral microbiology · 2025Review
- Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life.Frontiers in pediatrics · 2025Review
- Development of the breastfed infant oral microbiome over the first two years of life in the BLOSOM Cohort.Frontiers in cellular and infection microbiology · 2025Article
- Oral microbiota in an aging Swedish population with high dental disease burden: an observational registry-based study.Frontiers in oral health · 2025Article
- Oral Microbiota Development in the First 60 Months: A Longitudinal Study.Journal of dental research · 2024Article
- Impact of intrapartum antibiotic prophylaxis on the oral and fecal bacteriomes of children in the first week of life.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life determinants of the oral microbiota have not been thoroughly elucidated. We studied the association of birth and early childhood characteristics with oral microbiota composition using 16 S ribosomal RNA (rRNA) gene sequencing in a population-based Swedish cohort of 59 children sampled at 6, 12 and 24 months of age. Repeated-measurement regression models adjusted for potential confounders confirmed and expanded previous knowledge about the profound shift of oral microbiota composition in early life. These alterations included increased alpha diversity, decreased beta diversity and alteration of bacterial composition with changes in relative abundance of 14 of the 20 most common operational taxonomic units (OTUs). We also found that birth characteristics, breastfeeding and antibiotic use were associated with overall phyla distribution and/or with the relative abundance of specific OTUs. Further, we detected a novel link between morning salivary cortisol level, a physiological marker of neuroendocrine activity and stress, and overall phyla distribution as well as with decreased abundance of the most common OTU mapped to the Streptococcaceae family. In conclusion, a major part of the maturation of the oral microbiome occurs during the first two years of life, and this development may be influenced by early life circumstances.
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Registered trials
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