Evidence map›Paper›PMID 31836685›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2020

Radiation Dosimetry and Biodistribution of

Catherine Meyer, Magnus Dahlbom, Thomas Lindner, Sebastien Vauclin, Christine Mona, Roger Slavik, Johannes Czernin, Uwe Haberkorn, Jeremie Calais

6 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 136 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 7 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05172310 phase1recruitingnot on this mapstarted 2021, after this paper: background citation

PET Imaging of Tumors in Pancreas, Bile Ducts, Stomach and Ovaries by a Novel Tracer, 68Ga-FAPI-46 = Fibroblast Activation Protein Inhibitor

TypeinterventionalSponsorKarolinska University HospitalRan2021 to 2029Enrolled410ConditionsPancreatic Neoplasms, Stomach Neoplasms, Bile Duct Neoplasms, Epithelial Ovarian CancerArms68Ga-FAPI-46, PET/CT
NCT05687747 phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Single Centre Prospective Evaluation of 68Gallium-FAPI PET/MRI in Hepatocellular Carcinoma

TypeinterventionalSponsorNational University Hospital, SingaporeRan2023 to 2026Enrolled100ConditionsHepatocellular CarcinomaArmsRadiolabelled tracer, 68Gallium-FAPI-46 PET/MRI
NCT05898854 phase2completednot on this mapstarted 2024, after this paper: background citation

[68Ga]Ga-FAPI PET/CT: The Dagnostic Accuracy for Primary Staging and Re-staging After Chemotherapy in Patients With Gastric and Gastro-esophageal Junctional Cancer

TypeinterventionalSponsorAalborg University HospitalRan2024 to 2025Enrolled20ConditionsGastric Cancer, Gastro Esophageal Junctional Cancer, CancerArms68Ga-FAPi-46
NCT05903807 phase2terminatednot on this mapstarted 2023, after this paper: background citation

[68Ga]Ga-FAPI-46 PET/CT: The Diagnostic Accuracy for Primary Staging and Re-staging of Patients With Ovarian Cancer

TypeinterventionalSponsorAalborg University HospitalRan2023 to 2026Enrolled20ConditionsOvarian CancerArms68Ga-FAPi-46
NCT06568783 phase2not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Evaluation of Patients With Refractory Dermatomyositis Using [18F]- Fibroblast Activation Protein Inhibitor-74 (FAPI-74) PET/MRI Imaging

TypeinterventionalSponsorFarshad MoradiRan2024 to 2028Enrolled21ConditionsRefractory DermatomyostitisArms[18F]-FAPI-74
NCT07215182 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

[68Ga]Ga-FAPI PET/CT for Response Evaluation During Immune Checkpoint Inhibitor Therapy in Malignant Melanoma

TypeinterventionalSponsorBarbara Malene FischerRan2025 to 2027Enrolled20ConditionsMalignant Melanoma Stage IVArms[68Ga]Ga-FAPI-46
3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 7 syntheses or guidelines pooled it, 224 citations in OpenAlex.

  1. Head-to-head comparative study of [Frontiers in oncology · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Comparison of [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  9. Trial
  10. Head-to-head comparison ofAnnals of nuclear medicine · 2025
    Trial
  11. Non-specific uptake ofScientific reports · 2024
    Trial
  12. Trial
  13. Non-malignant findings of focalEuropean journal of nuclear medicine and molecular imaging · 2021
    Trial
  14. Early post-infarct fibroblast activation protein-targeted PET/CT withEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  15. Comparative Evaluation of [Molecular imaging and biology · 2026
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Swin UNETR-based prediction of [BMC medical imaging · 2026
    Article

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Catherine MeyerPhysics and Biology in Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, UCLA, Los Angeles, California.
Magnus DahlbomPhysics and Biology in Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, UCLA, Los Angeles, California.
Thomas LindnerDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Sebastien VauclinDOSIsoft SA, Cachan, France.
Christine MonaAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California.
Roger SlavikPhysics and Biology in Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, UCLA, Los Angeles, California.
Johannes CzerninAhmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, California.
Uwe HaberkornDepartment of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Jeremie CalaisPhysics and Biology in Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, UCLA, Los Angeles, California jcalais@mednet.ucla.edu.
UCLA Jonsson Comprehensive Cancer CenterUniversity Hospital Heidelberg · DEUniversity of California, Los Angeles · USDKFZ-ZMBH Alliance · DE

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P30 CA016042NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Targeting cancer-associated fibroblasts (CAFs) has become an attractive goal for diagnostic imaging and therapy because they can constitute as much as 90% of a tumor mass. The serine protease fibroblast activation protein (FAP) is overexpressed selectively in CAFs, drawing interest in FAP as a stromal target. The quinoline-based FAP inhibitor (FAPI) PET tracer

Indexed as

Positron Emission Tomography Computed TomographyAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasmsQuinolinesRadiometryRetrospective StudiesTissue Distribution68Ga-FAPIQuinolines68GabiodistributiondosimetryFAPIPET/CT

Identifiers

PMID31836685
PMCPMC7413240
OpenAlexW2995884929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.