Evidence map›Paper›PMID 31836321›Full record

ArticleNeuron2020

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals.

Deanna J Greene, Scott Marek, Evan M Gordon, Joshua S Siegel, Caterina Gratton, Timothy O Laumann, Adrian W Gilmore, Jeffrey J Berg, Annie L Nguyen, Donna Dierker and 13 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 142 papers.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 255 citations in OpenAlex.

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  14. Representing Brain-Behavior Associations by Retaining High-Motion Minoritized Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  15. Article
  16. Article
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  18. The Cognitive-Affective Social Processing and Emotion Regulation (CASPER) model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  19. Article
  20. Considerations for conducting developmental neuroimaging research on mental health topics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 1 country.

Deanna J GreeneDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: dgreene@wustl.edu.
Scott MarekDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: smarek@wustl.edu.
Evan M GordonVISN17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.
Joshua S SiegelDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Caterina GrattonDepartment of Psychology, Northwestern University, Evanston, IL, USA; Department of Neurology, Northwestern University, Evanston, IL, USA.
Timothy O LaumannDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Adrian W GilmoreDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jeffrey J BergDepartment of Psychology, New York University, New York, NY, USA.
Annie L NguyenDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Donna DierkerMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Andrew N VanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Mario OrtegaDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Dillan J NewboldDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Jacqueline M HamptonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Ashley N NielsenInstitute for Innovations in Developmental Sciences, Northwestern University, Chicago, IL, USA.
Kathleen B McDermottMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Psychological and Brain Sciences, Washington University, St. Louis, MO, USA.
Jarod L RolandDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Scott A NorrisDepartment of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Steven M NelsonVISN17 Center of Excellence for Research on Returning War Veterans, Waco, TX, USA; Center for Vital Longevity, School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA; Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA.
Abraham Z SnyderMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Bradley L SchlaggarKennedy Krieger Institute, Baltimore, MD, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steven E PetersenMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Nico U F DosenbachMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA; Program in Occupational Therapy, Washington University, St. Louis, MO, USA. Electronic address: dosenbachn@wustl.edu.
Washington University in St. Louis · USMallinckrodt (United States) · USNorthwestern University · USUniversity of California, San Francisco · USBaylor University · USJohns Hopkins Medicine · USNeurological Surgery · USNew York University · USThe University of Texas at Dallas · US

Funding

Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI MOLEY, KELLE H · 2015 to 2019
$7.1M
Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Sources and Functional Consequences of Individual Differences in Human Functional Brain Networks Related to Controlled BehaviorR01MH118370 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GRATTON, CATERINA · 2019 to 2023
$3.4M
NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI RAICHLE, MARCUS E · 2016 to 2019
$2.4M
Washington University Psychiatry Residency Research Education ProgramR25MH112473 · NIMH · WASHINGTON UNIVERSITY · PI NURI B FARBER, Timothy Eric Spiegel · 2018 to 2026
$1.6M
PEDIATRIC BRAIN INJURY RECOVERY VIA USE-DRIVEN FUNCTIONAL NETWORK REORGANIZATIONK23NS088590 · NINDS · WASHINGTON UNIVERSITY · PI DOSENBACH, NICO · 2015 to 2019
$886k
PREDICTING OUTCOME IN CHILDREN WITH TIC DISORDERS USING NEUROIMAGING DATAK01MH104592 · NIMH · WASHINGTON UNIVERSITY · PI GREENE, DEANNA JACQUELYN · 2014 to 2018
$723k
Dynamics in resting and task-based functional connectivityF30MH100872 · NIMH · WASHINGTON UNIVERSITY · PI LAUMANN, TIMOTHY OTTO · 2013 to 2016
$145k
Human network plasticity caused by disuseF31NS110332 · NINDS · WASHINGTON UNIVERSITY · PI NEWBOLD, DILLAN JACOB · 2019 to 2021
$94k
Neuroimaging-based identification of Traumatic Brain Injury subtypesIK2CX001680 · VA · OLIN TEAGUE VETERANS CENTER · PI GORDON, EVAN M. · 2019 to 2021
–
CSRD VA IK2 CX001680NICHD NIH HHS U54 HD087011NIMH NIH HHS F30 MH100872NIMH NIH HHS K01 MH104592NIMH NIH HHS R01 MH118370NIMH NIH HHS R25 MH112473NIMH NIH HHS T32 MH100019NINDS NIH HHS F31 NS110332NINDS NIH HHS K23 NS088590NINDS NIH HHS P30 NS098577
6 · The paper itself

Abstract

The basal ganglia, thalamus, and cerebral cortex form an interconnected network implicated in many neurological and psychiatric illnesses. A better understanding of cortico-subcortical circuits in individuals will aid in development of personalized treatments. Using precision functional mapping-individual-specific analysis of highly sampled human participants-we investigated individual-specific functional connectivity between subcortical structures and cortical functional networks. This approach revealed distinct subcortical zones of network specificity and multi-network integration. Integration zones were systematic, with convergence of cingulo-opercular control and somatomotor networks in the ventral intermediate thalamus (motor integration zones), dorsal attention and visual networks in the pulvinar, and default mode and multiple control networks in the caudate nucleus. The motor integration zones were present in every individual and correspond to consistently successful sites of deep brain stimulation (DBS; essential tremor). Individually variable subcortical zones correspond to DBS sites with less consistent treatment effects, highlighting the importance of PFM for neurosurgery, neurology, and psychiatry.

Indexed as

AdultBasal GangliaFemaleHumansMagnetic Resonance ImagingMaleNerve NetThalamusYoung Adultbasal gangliabrain networksdeep brain stimulationfunctional connectivityprecision functional mappingresting statesubcortexthalamus

Identifiers

PMID31836321
PMCPMC7035165
OpenAlexW2995276946

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.