Evidence map›Paper›PMID 31835845›Full record

ArticlePharmacy (Basel, Switzerland)2019

Implementation of an Extended-Infusion Piperacillin-Tazobactam Dosing Protocol: Unexpected Findings when Monitoring Safety and Compliance with Smart Pump Technology.

Nathaniel J Rhodes, Jenna Lopez, Cecilia K Pham, Helga Brake, Michael Fotis, Spencer E Harpe, Sean Avedissian, Marc H Scheetz

Open access · goldAbstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Nathaniel J RhodesDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA.ORCID 0000-0002-0018-5434
Jenna LopezDepartment of Pharmacy, Loyola University Medical Center, Maywood, IL 60153, USA.
Cecilia K PhamDepartment of Pharmacy, Rite Aid Pharmacy #5910, Benicia, CA 94510, USA.
Helga BrakeThe Institute for Innovations in Care and Quality, Illinois Hospital Association, Naperville, IL 60563, USA.
Michael FotisFeinberg School of Medicine, Medical Education, Northwestern University, Chicago, IL 60611, USA.
Spencer E HarpeDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA.
Sean AvedissianAntiviral Pharmacology Laboratory, University of Nebraska Medical Center (UNMC) Center for Drug Discovery, UNMC, Omaha, NE 68198, USA.ORCID 0000-0002-0935-6455
Marc H ScheetzDepartment of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, IL 60515, USA.ORCID 0000-0002-1091-6130
Midwestern University · USAmerican Hospital Association · USLoyola University Medical Center · USNorthwestern University · USRite Aid (United States) · USUniversity of Nebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compliance with recommended infusion rates was evaluated before, during, and after the implementation of extended-infusion (EI) piperacillin-tazobactam at an academic medical center. Software-controlled infusion-pump alert data were studied for piperacillin-tazobactam administrations before and after implementation of a four-hour EI protocol. Compliance was analyzed 16 weeks before (pre-EI), two weeks after (peri-EI), and an additional 16 weeks after (post-EI) protocol implementation. We defined potential harm as a programmed infusion rate exceeding the recommended rate, possible harm as a programmed infusion aborted by the user, and compliance as reversion to recommended rates. Potential and possible harm were standardized to 1000 patient days. Overall, 3110 alerts were identified during the period. Potential harm per 1000 patient days for pre-, peri-, and post-EI were 0, 6.12, and 1.05 (

Indexed as

antimicrobial stewardshipextended-infusionpiperacillin-tazobactamsmart pump

Identifiers

PMID31835845
PMCPMC6958524
OpenAlexW2994865115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.