Evidence map›Paper›PMID 31835836›Full record

ArticleToxins2019

Analysis of Pyrrolizidine Alkaloids in Queensland Honey: Using Low Temperature Chromatography to Resolve Stereoisomers and Identify Botanical Sources by UHPLC-MS/MS.

Natasha L Hungerford, Steve J Carter, Shalona R Anuj, Benjamin L L Tan, Darina Hnatko, Christopher L Martin, Elipsha Sharma, Mukan Yin, Thao T P Nguyen, Kevin J Melksham and 1 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Metabolite Production inmSystems · 2022
    Article
  8. Rumen Metabolism ofJournal of agricultural and food chemistry · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Mineral and Trace Element Analysis of Australian/QueenslandInternational journal of environmental research and public health · 2020
    Article
  16. Article
  17. Spread ofToxins · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Natasha L HungerfordQueensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Brisbane, QLD 4072, Australia.
Steve J CarterForensic and Scientific Services, Queensland Health, Brisbane, QLD 4108, Australia.
Shalona R AnujForensic and Scientific Services, Queensland Health, Brisbane, QLD 4108, Australia.
Benjamin L L TanForensic and Scientific Services, Queensland Health, Brisbane, QLD 4108, Australia.
Darina HnatkoForensic and Scientific Services, Queensland Health, Brisbane, QLD 4108, Australia.
Christopher L MartinQueensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Brisbane, QLD 4072, Australia.
Elipsha SharmaQueensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Brisbane, QLD 4072, Australia.
Mukan YinQueensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Brisbane, QLD 4072, Australia.
Thao T P NguyenQueensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Brisbane, QLD 4072, Australia.
Kevin J MelkshamForensic and Scientific Services, Queensland Health, Brisbane, QLD 4108, Australia.
Mary T FletcherQueensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, Brisbane, QLD 4072, Australia.
The University of Queensland · AUQueensland Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrrolizidine alkaloids (PAs) are a diverse group of plant secondary metabolites with known varied toxicity. Consumption of 1,2-unsaturated PAs has been linked to acute and chronic liver damage, carcinogenicity and death, in livestock and humans, making their presence in food of concern to food regulators in Australia and internationally. In this survey, honey samples sourced from markets and shops in Queensland (Australia), were analysed by high-resolution Orbitrap UHPLC-MS/MS for 30 common PAs. Relationships between the occurrence of pyrrolizidine alkaloids and the botanical origin of the honey are essential as pyrrolizidine alkaloid contamination at up to 3300 ng/g were detected. In this study, the predominant alkaloids detected were isomeric PAs, lycopsamine, indicine and intermedine, exhibiting identical MS/MS spectra, along with lesser amounts of each of their

Indexed as

Chromatography, High Pressure LiquidFood ContaminationHoneyPlantsPyrrolizidine AlkaloidsQueenslandStereoisomerismTandem Mass SpectrometryTemperaturePyrrolizidine AlkaloidsHeliotropium amplexicaulehoneyindicineLC-MSlycopsamineParsonsia stramineapyrrolizidine alkaloid

Identifiers

PMID31835836
PMCPMC6950414
OpenAlexW2995275030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.