Evidence map›Paper›PMID 31835767›Full record

ArticleInternational journal of molecular sciences2019

Metabolomic Profile of BALB/c Macrophages Infected with

Sandra Marcia Muxel, Maricruz Mamani-Huanca, Juliana Ide Aoki, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter, Ángeles López-Gonzálvez, Coral Barbas

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  5. iScience · 2023
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  9. Article
  10. Major Molecular Factors Related toFrontiers in immunology · 2022
    Review
  11. Article
  12. Metabolomic Reprogramming of C57BL/6-Macrophages during Early Infection withInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sandra Marcia MuxelDepartamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP 05508-090, Brazil.ORCID 0000-0003-0118-5361
Maricruz Mamani-HuancaCentre for Metabolomics and Bioanalysis (CEMBIO), Departamento de Química e Bioquímica, Facultad de Farmacia, Universidad CEU San Pablo, Campus Monteprincipe, Boadilla del Monte, 28660 Madrid, Spain.
Juliana Ide AokiDepartamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP 05508-090, Brazil.
Ricardo Andrade ZampieriDepartamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP 05508-090, Brazil.
Lucile Maria Floeter-WinterDepartamento de Fisiologia, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP 05508-090, Brazil.
Ángeles López-GonzálvezCentre for Metabolomics and Bioanalysis (CEMBIO), Departamento de Química e Bioquímica, Facultad de Farmacia, Universidad CEU San Pablo, Campus Monteprincipe, Boadilla del Monte, 28660 Madrid, Spain.ORCID 0000-0002-6363-7135
Coral BarbasCentre for Metabolomics and Bioanalysis (CEMBIO), Departamento de Química e Bioquímica, Facultad de Farmacia, Universidad CEU San Pablo, Campus Monteprincipe, Boadilla del Monte, 28660 Madrid, Spain.ORCID 0000-0003-4722-491X
Universidad San Pablo CEU · ESUniversidade de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 406351/2018-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/23512-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/24693-9
6 · The paper itself

Abstract

backgroundLeishmaniases are neglected tropical diseases that are caused by

methodsThe metabolites of infected macrophages were analyzed by capillary electrophoresis coupled with mass spectrometry (CE-MS). The metabolic fingerprints analysis provided the dual profile from the host and parasite.

resultsWe observed increased levels of proline, glutamic acid, glutamine, L-arginine, ornithine, and putrescine in infected-

conclusionsThe metabolome fingerprint indicated that

Indexed as

MetabolomicsAnimalsArginineDiscriminant AnalysisFemaleLeast-Squares AnalysisLeishmania mexicanaMacrophagesMetabolic Networks and PathwaysMetabolomeMice, Inbred BALB CParasitesProlineArginineProlineargininebone marrow-derived macrophagesmetabolitespolyamines pathway

Identifiers

PMID31835767
PMCPMC6940984
OpenAlexW2995959387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.