Evidence map›Paper›PMID 31835699›Full record

ReviewMolecules (Basel, Switzerland)2019

Much More Than a Pleasant Scent: A Review on Essential Oils Supporting the Immune System.

Agnes Peterfalvi, Eva Miko, Tamas Nagy, Barbara Reger, Diana Simon, Attila Miseta, Boldizsár Czéh, Laszlo Szereday

Registry-linked trialAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06435104 (Effects of Aromatherapy on Anxiety and Tumor Immunity of Early Breast Cancer Patients,a Pilot Study), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06435104 phase2not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Aromatherapy on Anxiety and Tumor Immunity of Early Breast Cancer Patients,a Pilot Study

TypeinterventionalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2024 to 2027Enrolled30ConditionsEarly Breast CancerArmsneoadjuvant chemotherapy, aromatherapy
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Nature Exposure and Its Effects on Immune System Functioning: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  3. Review
  4. Phytomedicines and conventional drugs in scabies management.GMS hygiene and infection control · 2026
    Review
  5. Review
  6. Article
  7. Microorganisms · 2025
    Article
  8. Article
  9. Review
  10. Antioxidant Activity of Essential Oils from Pinaceae Species.Antioxidants (Basel, Switzerland) · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Essential Oils againstMolecules (Basel, Switzerland) · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Agnes PeterfalviDepartment of Laboratory Medicine, Medical School, University of Pecs, Ifjusag utja 13., 7624 Pecs, Hungary.
Eva MikoDepartment of Medical Microbiology and Immunology, Medical School, University of Pecs, Szigeti ut 12., 7624 Pecs, Hungary.
Tamas NagyDepartment of Laboratory Medicine, Medical School, University of Pecs, Ifjusag utja 13., 7624 Pecs, Hungary.ORCID 0000-0001-5437-1411
Barbara RegerDepartment of Laboratory Medicine, Medical School, University of Pecs, Ifjusag utja 13., 7624 Pecs, Hungary.
Diana SimonDepartment of Immunology and Biotechnology, Medical School, University of Pecs, Szigeti ut 12., 7624 Pecs, Hungary.
Attila MisetaDepartment of Laboratory Medicine, Medical School, University of Pecs, Ifjusag utja 13., 7624 Pecs, Hungary.
Boldizsár CzéhDepartment of Laboratory Medicine, Medical School, University of Pecs, Ifjusag utja 13., 7624 Pecs, Hungary.
Laszlo SzeredayDepartment of Medical Microbiology and Immunology, Medical School, University of Pecs, Szigeti ut 12., 7624 Pecs, Hungary.ORCID 0000-0002-1208-2969

Funding

European Social Fund EFOP-3.6.2-16-2017-00008PTE AOK-KA-2019-03 of the Medical School of the University of Pecs AOK-KA-2019-03The Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary 20765-3/2018/FEKUTSTRAT 5th thematic program of the University of Pecs
6 · The paper itself

Abstract

The augmenting acceptance and application of herbal medicine in prevention and treatment of diseases also involve the use of plant essential oils (EOs) through different routes of administration (aromatherapy). Scientific data supporting the efficacy of certain herbal products are continuously growing; however, the cumulative evidence is not always sufficient. The anti-inflammatory properties of EOs have been investigated more extensively and also reviewed in different settings, but so far, our review is the first to summarize the immune-supporting properties of EOs. Our aim here is to synthesize the currently available data on the immune function enhancing effects of EOs. An online search was conducted in the PubMed database, which was terminated at the end of July 2019. Other articles were found in the reference lists of the preselected papers. Studies that applied whole EOs with known components, or single EO constituents under in vitro or in vivo laboratory conditions, or in human studies, and de facto measured parameters related to immune function as outcome measures were included. Two specific fields, EO dietary supplementation for livestock and fish, and forest bathing are also explored. Some EOs, particularly eucalyptus and ginger, seem to have immune function enhancing properties in multiple studies.

Indexed as

Adaptive ImmunityAnimalsAnti-Inflammatory AgentsAromatherapyHumansImmunity, InnateOils, VolatilePlant OilsAnti-Inflammatory AgentsOils, VolatilePlant Oilsdietary supplementationessential oilseucalyptusforest bathinggingerherbal medicineimmune enhancementimmune functionsimmune system

Identifiers

PMID31835699
PMCPMC6943609

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.