Evidence map›Paper›PMID 31835645›Full record

ArticleNutrients2019

Ellagic Acid Inhibits Extracellular Acidity-Induced Invasiveness and Expression of COX1, COX2, Snail, Twist 1, and c-myc in Gastric Carcinoma Cells.

Sung-Chul Lim, Hyoin Hwang, Song Iy Han

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sung-Chul LimDepartment of Pathology, College of Medicine, Chosun University, Gwangju 61452, Korea.ORCID 0000-0001-6179-691X
Hyoin HwangBioBank, Chosun University Hospital, Gwangju 61452, Korea.
Song Iy HanDivision of Premedical Science, College of Medicine, Chosun University, Gwangju 61452, Korea.ORCID 0000-0003-4975-480X
Chosun University · KR

Funding

the National Research Foundation of Korea (NRF) funded by the Ministry of Education NRF-2015R1D1A1A01060533 and NRF-2018R1D1A1B07046430
6 · The paper itself

Abstract

Extracellular acidity has been implicated in enhanced malignancy and metastatic features in various cancer cells. Gastric cancer cell lines (AGS and SNU601) maintained in an acidic medium have increased motility and invasiveness. In this study, we investigated the effect of ellagic acid, a plant-derived phenolic compound, on the acidity-promoted migration and invasion of gastric cancer cells. Treating cells maintained in acidic medium with ellagic acid inhibited acidity-mediated migration and invasion, and reduced the expression of MMP7 and MMP9. Examining regulatory factors contributing to the acidity-mediated invasiveness, we found that an acidic pH increased the expression of COX1 and COX2; importantly, expression decreased under the ellagic acid treatment. The general COX inhibitor, sulindac, also decreased acidity-mediated invasion and expression of MMP7 and MMP9. In addition, acidity increased the mRNA protein expression of transcription factors snail, twist1, and c-myc; these were also reduced by ellagic acid. Together, these results suggest that ellagic acid suppresses acidity-enhanced migration and invasion of gastric cancer cells via inhibition of the expression of multiple factors (COX1, COX2, snail, twist1, and c-myc); for this reason, it may be an effective agent for cancer treatment under acidosis.

Indexed as

Cell Line, TumorCell MovementCyclooxygenase 1Cyclooxygenase 2Ellagic AcidExtracellular SpaceGene Expression Regulation, NeoplasticHumansHydrogen-Ion ConcentrationMatrix Metalloproteinase 7Matrix Metalloproteinase 9Neoplasm InvasivenessNuclear ProteinsSignal TransductionSnail Family Transcription FactorsStomach NeoplasmsCyclooxygenase 1Cyclooxygenase 2Ellagic AcidMatrix Metalloproteinase 7Matrix Metalloproteinase 9MMP7 protein, humanMMP9 protein, humanNuclear ProteinsSNAI1 protein, humanSnail Family Transcription FactorsTWIST1 protein, humanTwist-Related Protein 1ellagic acidextracellular acidityinvasion

Identifiers

PMID31835645
PMCPMC6950616
OpenAlexW2996673575

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.