Evidence map›Paper›PMID 31835583›Full record

ArticleMolecules (Basel, Switzerland)2019

Preparative Method for Asymmetric Synthesis of (

Jianlin Han, Ryosuke Takeda, Xinyi Liu, Hiroyuki Konno, Hidenori Abe, Takahiro Hiramatsu, Hiroki Moriwaki, Vadim A Soloshonok

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Special Issue: Development of Asymmetric Synthesis.Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jianlin HanCollege of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China.ORCID 0000-0002-3817-0764
Ryosuke TakedaHamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.ORCID 0000-0003-4502-8368
Xinyi LiuCollege of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, Jiangsu, China.
Hiroyuki KonnoDepartment of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata 992‑8510, Japan.ORCID 0000-0002-6629-6102
Hidenori AbeHamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Takahiro HiramatsuHamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Hiroki MoriwakiHamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka 533-0024, Japan.
Vadim A SoloshonokDepartment of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain.ORCID 0000-0003-0681-4526

Funding

National Natural Science Foundation of China 21761132021
6 · The paper itself

Abstract

Enantiomerically pure derivatives of 2-amino-4,4,4-trifluorobutanoic acid are in great demand as bioisostere of leucine moiety in the drug design. Here, we disclose a method specifically developed for large-scale (>150 g) preparation of the target (

Indexed as

AlkylationButyratesHydrocarbons, FluorinatedMolecular StructureStereoisomerism2-amino-4,4,4-trifluorobutanoic acidButyratesHydrocarbons, Fluorinatedasymmetric synthesisfluorinated amino acidglycine Schiff baselarge-scale synthesisNi complex

Identifiers

PMID31835583
PMCPMC6943542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.