Evidence map›Paper›PMID 31835542›Full record

ReviewDiagnostics (Basel, Switzerland)2019

Arrhythmogenic Inflammatory Cardiomyopathy in Autoimmune Rheumatic Diseases: A Challenge for Cardio-Rheumatology.

Sophie I Mavrogeni, George Markousis-Mavrogenis, Constantina Aggeli, Dimitris Tousoulis, George D Kitas, Genovefa Kolovou, Efstathios K Iliodromitis, Petros P Sfikakis

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Correlation between cardiovascular magnetic resonance features and clinical characteristics of cardiac involvement in connective tissue diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Molecular Basis of Inflammation in the Pathogenesis of Cardiomyopathies.International journal of molecular sciences · 2020
    Review
  9. Arrhythmias Associated with Inflammatory Cardiomyopathies.Current treatment options in cardiovascular medicine · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sophie I MavrogeniOnassis Cardiac surgery Center, 17674 Athens, Greece.
George Markousis-MavrogenisOnassis Cardiac surgery Center, 17674 Athens, Greece.
Constantina AggeliFirst Cardiac Clinic, Hippokration University Hospital, 17674 Athens, Greece.
Dimitris TousoulisFirst Cardiac Clinic, Hippokration University Hospital, 17674 Athens, Greece.
George D KitasArthritis Research UK Epidemiology Unit, Manchester University, Manchester M13 9PT, UK.
Genovefa KolovouOnassis Cardiac surgery Center, 17674 Athens, Greece.
Efstathios K IliodromitisSecond Cardiac Clinic, Attikon University Hospital, 17674 Athens, Greece.
Petros P SfikakisFirst Department of Propeudeutic and Internal medicine, Laikon Hospital, Athens University Medical School, 17674 Athens, Greece.
Onassis Cardiac Surgery Center · GRHippocration General Hospital · GRUniversity General Hospital Attikon · GRUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ventricular arrhythmia (VA) in autoimmune rheumatic diseases (ARD) is an expression of autoimmune inflammatory cardiomyopathy (AIC), caused by structural, electrical, or inflammatory heart disease, and has a serious impact on a patient's outcome. Myocardial scar of ischemic or nonischemic origin through a re-entry mechanism facilitates the development of VA. Additionally, autoimmune myocardial inflammation, either isolated or as a part of the generalized inflammatory process, also facilitates the development of VA through arrhythmogenic autoantibodies and inflammatory channelopathies. The clinical presentation of AIC varies from oligo-asymptomatic presentation to severe VA and sudden cardiac death (SCD). Both positron emission tomography (PET) and cardiovascular magnetic resonance (CMR) can diagnose AIC early and be useful tools for the assessment of therapies during follow-ups. The AIC treatment should be focused on the following: (1) early initiation of cardiac medication, including ACE-inhibitors, b-blockers, and aldosterone antagonists; (2) early initiation of antirheumatic medication, depending on the underlying disease; and (3) potentially implantable cardioverter-defibrillator (ICD) and/or ablation therapy in patients who are at high risk for SCD.

Indexed as

autoimmune inflammatory cardiomyopathyautoimmune myocarditisautoimmune rheumatic diseasescardiovascular magnetic resonancepositron emission tomography

Identifiers

PMID31835542
PMCPMC6963646
OpenAlexW2995515139

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.