Evidence map›Paper›PMID 31835486›Full record

ArticleInternational journal of molecular sciences2019

Aldh2 Attenuates Stem Cell Factor/Kit-Dependent Signaling and Activation in Mast Cells.

Do-Kyun Kim, Young-Eun Cho, Byoung-Joon Song, Toshihiro Kawamoto, Dean D Metcalfe, Ana Olivera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Phospholipase D regulates ferroptosis signal transduction in mouse spleen hypoxia response.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
  2. KIT as a master regulator of the mast cell lineage.The Journal of allergy and clinical immunology · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Do-Kyun KimMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Young-Eun ChoSection of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, MD 20892, USA.
Byoung-Joon SongSection of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-3954-3497
Toshihiro KawamotoOccupational Health Research and Development Center, Japan Industrial Safety and Health Association, Tokyo 108-0014, Japan.
Dean D MetcalfeMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-7781-8260
Ana OliveraMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
National Institutes of Health · USNational Institute on Alcohol Abuse and Alcoholism · USJapan Industrial Safety and Health Association · JP

Funding

Identification and Characterization of Signaling Pathways and Mediators Regulating Mast Cell-Related DisordersZIAAI001206 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI OLIVERA, ANA · 2015 to 2025
$11.3M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases AI001206
6 · The paper itself

Abstract

Mitochondrial aldehyde dehydrogenase (ALDH2) metabolizes endogenous and exogenous aldehydes and protects cells against oxidative injury. Inactivating genetic polymorphisms in humans are common and associate with alcohol flush reactions. However, whether mast cell Aldh2 activity impacts normal mast cell responses is unknown. Using bone marrow-derived mast cells from

Indexed as

Aldehyde Dehydrogenase, MitochondrialAnimalsCell LineCell ProliferationGene Knockout TechniquesMast CellsPhosphorylationProtein Tyrosine Phosphatase, Non-Receptor Type 6Proto-Oncogene Proteins c-kitReactive Oxygen SpeciesSignal TransductionStem Cell FactorAldehyde Dehydrogenase, MitochondrialALDH2 protein, mouseKit protein, mouseProtein Tyrosine Phosphatase, Non-Receptor Type 6Proto-Oncogene Proteins c-kitPtpn6 protein, mouseReactive Oxygen SpeciesStem Cell FactorAldh2 deficiencyKitmast cell activationmast cellsproliferationShp-1

Identifiers

PMID31835486
PMCPMC6940998
OpenAlexW2994746021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.