Evidence map›Paper›PMID 31835372›Full record

ReviewInternational journal of molecular sciences2019

Polyglycerol Hyperbranched Polyesters: Synthesis, Properties and Pharmaceutical and Biomedical Applications.

Alexandra Zamboulis, Eirini A Nakiou, Evi Christodoulou, Dimitrios N Bikiaris, Eleana Kontonasaki, Liliana Liverani, Aldo R Boccaccini

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 82 citations in OpenAlex.

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  17. Barrier membranes for tissue regeneration in dentistry.Biomaterial investigations in dentistry · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Alexandra ZamboulisLaboratory of Polymer Chemistry & Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Eirini A NakiouLaboratory of Polymer Chemistry & Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Evi ChristodoulouLaboratory of Polymer Chemistry & Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-2730-0778
Dimitrios N BikiarisLaboratory of Polymer Chemistry & Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8458-4952
Eleana KontonasakiDepartment of Dentistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Liliana LiveraniInstitute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany.ORCID 0000-0002-4270-4861
Aldo R BoccacciniInstitute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, Cauerstr. 6, 91058 Erlangen, Germany.ORCID 0000-0002-7377-2955
Aristotle University of Thessaloniki · GRFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

Τhe authors wish to acknowledge funding of this research by DAAD, Germany, in the frame of Greek-German collaboration (IKYDA 2018-2020). IKYDA 2018-2020
6 · The paper itself

Abstract

In a century when environmental pollution is a major issue, polymers issued from bio-based monomers have gained important interest, as they are expected to be environment-friendly, and biocompatible, with non-toxic degradation products. In parallel, hyperbranched polymers have emerged as an easily accessible alternative to dendrimers with numerous potential applications. Glycerol (Gly) is a natural, low-cost, trifunctional monomer, with a production expected to grow significantly, and thus an excellent candidate for the synthesis of hyperbranched polyesters for pharmaceutical and biomedical applications. In the present article, we review the synthesis, properties, and applications of glycerol polyesters of aliphatic dicarboxylic acids (from succinic to sebacic acids) as well as the copolymers of glycerol or hyperbranched polyglycerol with poly(lactic acid) and poly(ε-caprolactone). Emphasis was given to summarize the synthetic procedures (monomer molar ratio, used catalysts, temperatures, etc.,) and their effect on the molecular weight, solubility, and thermal and mechanical properties of the prepared hyperbranched polymers. Their applications in pharmaceutical technology as drug carries and in biomedical applications focusing on regenerative medicine are highlighted.

Indexed as

Biocompatible MaterialsDendrimersDrug CarriersGlycerolPolyestersPolymersHumansRegenerative MedicineBiocompatible MaterialsDendrimersDrug CarriersGlycerolPolyesterspolyglycerolPolymerscatalystsesterification reactionshyperbranched polymersmedical and biomedical applicationspolycondensationpolyglycerol polyesters

Identifiers

PMID31835372
PMCPMC6940955
OpenAlexW2993528492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.