Evidence map›Paper›PMID 31835310›Full record

ArticleMedicines (Basel, Switzerland)2019

Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists.

Shawn G Kwatra, Emily Boozalis, Amy H Huang, Cory Nanni, Raveena Khanna, Kyle A Williams, Yevgeniy R Semenov, Callie M Roberts, Robert F Burns, Madison Krischak and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicines (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shawn G KwatraDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-3736-1515
Emily BoozalisDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0002-4231-7984
Amy H HuangDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.ORCID 0000-0003-2510-6269
Cory NanniDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.
Raveena KhannaDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.
Kyle A WilliamsDepartment of Dermatology, Johns Hopkins University, Baltimore, MD 21287, USA.
Yevgeniy R SemenovDivision of Dermatology, Washington University School of Medicine, St. Louis, MI 63110, USA.ORCID 0000-0002-7387-3094
Callie M RobertsDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.
Robert F BurnsDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.
Madison KrischakDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.
Madan M KwatraDepartment of Anesthesiology, Duke University, Durham, NC 27710, USA.
Duke University · USJohns Hopkins University · USWashington University in St. Louis · US

Funding

Truncated NK1R in GBM: Pharmacology and Relationship with Patient SurvivalR21NS078642 · NINDS · DUKE UNIVERSITY · PI KWATRA, MADAN M · 2012 to 2013
$396k
Dermatology Foundation Medical Dermatology GrantNIH HHS R21NS078642
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

aprepitantEGFRepidermal growth factor receptorerlotinibneurokinin1-receptorNK1Rpruritus

Identifiers

PMID31835310
PMCPMC6963385
OpenAlexW2991933738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.