Evidence map›Paper›PMID 31835157›Full record

ArticleCancer epidemiology2020

Gender of offspring and risk of ovarian cancer: The HOPE study.

Zhuxuan Fu, Kirsten Moysich, Roberta B Ness, Francesmary Modugno

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. What is new about ovarian malignancies?Contemporary oncology (Poznan, Poland) · 2021
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Zhuxuan FuDepartment of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. Electronic address: Zhuxuan.Fu@pitt.edu.
Kirsten MoysichRoswell Park Cancer Institute, Buffalo, NY, USA. Electronic address: Moysich@roswellpark.org.
Roberta B NessUniversity of Texas School of Public Health, Houston, TX, USA. Electronic address: Roberta.B.Ness@uth.tmc.edu.
Francesmary ModugnoWomens Cancer Research Program, Magee-Womens Research Institute and UPMC Hillman Cancer Center, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: modugnof@upmc.edu.
University of Pittsburgh · USRoswell Park Comprehensive Cancer Center · USThe University of Texas Health Science Center at Houston · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jessie Nedrow · 1988 to 2026
$158.0M
Inflammation and Ovarian CancerR01CA095023 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUNKER, CLAREANN H. · 2003 to 2008
$2.7M
OVARIAN CANCER RISK AND SURVIVAL IN BRCA CARRIERSK07CA080668 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MODUGNO, FRANCESMARY · 2000 to 2005
$661k
NCI NIH HHS K07 CA080668NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA095023
6 · The paper itself

Abstract

objectiveTo examine the association between gender of offspring and epithelial ovarian cancer (EOC).

methodsWe compared gender of offspring between 664 incident EOC cases and 1531 controls participating in a population-based study conducted in Pennsylvania, Ohio, and New York from 2003-2008. Multivariable unconditional logistic regression was used to calculate odds ratios (ORs) and 95 % confidence intervals (CIs) adjusting for potential confounders.

resultsBearing a male offspring was associated with an 8 % lower EOC risk; bearing all boys was associated with an 11 % lower risk. Compared to bearing all girls, bearing all boys was associated with a 14 % decrease risk. Increasing number of male offspring increased the protective effect (adjusted-OR: 0.92, 0.91, 0.84, for 1, 2, and 3+ boys compared to all girls). Results where similar when limiting cases to invasive disease and to the high-grade serous histotype.

conclusionFetal sex, which influences maternal hormonal milieu, may impact EOC risk.

Indexed as

AgedCase-Control StudiesFemaleGender IdentityHumansMiddle AgedOvarian NeoplasmsRisk FactorsCase-control studyEpithelial ovarian cancerGender of offspring

Identifiers

PMID31835157
PMCPMC6983354
OpenAlexW2995580007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.