Evidence map›Paper›PMID 31835092›Full record

ArticleProstaglandins, leukotrienes, and essential fatty acids2020

Loss of RAR-related orphan receptor alpha (RORα) selectively lowers docosahexaenoic acid in developing cerebellum.

Chuck T Chen, Joseph A Schultz, Sophie E Haven, Breanne Wilhite, Chi-Hsiu Liu, Jing Chen, Joseph R Hibbeln

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prostaglandins, leukotrienes, and essential fatty acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chuck T ChenSection on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, United States. Electronic address: tzuhuan.chen@nih.gov.
Joseph A SchultzSection on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, United States. Electronic address: Schultz.joseph2018@gmail.com.
Sophie E HavenSection on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, United States. Electronic address: sophieelizabethhaven@gmail.com.
Breanne WilhiteSection on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, United States. Electronic address: breanne.conway@tufts.edu.
Chi-Hsiu LiuDepartment of Ophthalmology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, United States. Electronic address: Chi-Hsiu.Liu@childrens.harvard.edu.
Jing ChenDepartment of Ophthalmology, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, United States. Electronic address: Jing.Chen@childrens.harvard.edu.
Joseph R HibbelnSection on Nutritional Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Room 3N-01, North Bethesda, MD 20852, United States. Electronic address: jhibbeln@mail.nih.gov.
National Institute on Alcohol Abuse and Alcoholism · USBoston Children's Hospital · USHarvard University · USNational Institutes of Health · US

Funding

Nutritional Effects On Essential Fatty Acid CompositionZIAAA000235 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HIBBELN, JOSEPH · 2009 to 2020
$8.2M
Essential Fatty Acids In Psychiatric DisordersZIAAA000115 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI HIBBELN, JOSEPH · 2009 to 2020
$7.8M
RORalpha mediates chronic subretinal inflammation associated with AMDR01EY024963 · NEI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, JING · 2015 to 2025
$4.2M
Intramural NIH HHS ZIA AA000115NEI NIH HHS R01 EY024963
6 · The paper itself

Abstract

Deficiency in retinoid acid receptor-related orphan receptor alpha (RORα) of staggerer mice results in extensive granule and Purkinje cell loss in the cerebellum as well as in learned motor deficits, cognition impairments and perseverative tendencies that are commonly observed in autistic spectrum disorder (ASD). The effects of RORα on brain lipid metabolism associated with cerebellar atrophy remain unexplored. The aim of this study is to examine the effects of RORα deficiency on brain phospholipid fatty acid concentrations and compositions. Staggerer mice (Rora

Indexed as

AnimalsBrainChromatography, GasDocosahexaenoic AcidsFatty Acids, Omega-3FemaleLipid MetabolismMaleMiceNuclear Receptor Subfamily 1, Group F, Member 1PhospholipidsDocosahexaenoic AcidsFatty Acids, Omega-3Nuclear Receptor Subfamily 1, Group F, Member 1PhospholipidsRora protein, mouseAutistic disorderCerebellumDevelopmentNuclear receptorPhospholipids

Identifiers

PMID31835092
PMCPMC7041906
OpenAlexW2991074548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.