Evidence map›Paper›PMID 31834999›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

FSTL-1 Attenuation Causes Spontaneous Smoke-Resistant Pulmonary Emphysema.

Matthew Henkel, Jessica Partyka, Alyssa D Gregory, Erick Forno, Michael H Cho, Taylor Eddens, Andrew R Tout, Nathan Salamacha, William Horne, Krithika S Rao and 8 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Entering the ring: circular RNA in pulmonary macrophage antibacterial responses.American journal of respiratory cell and molecular biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Update in Chronic Obstructive Pulmonary Disease 2020.American journal of respiratory and critical care medicine · 2021
    Article
  11. Article
  12. Innate Immune Responses and Pulmonary Diseases.Advances in experimental medicine and biology · 2021
    Article
  13. Article
  14. Article
  15. Update in Chronic Obstructive Pulmonary Disease 2019.American journal of respiratory and critical care medicine · 2020
    Review
  16. FSTL-1: A New Player in the Prevention of Emphysema.American journal of respiratory and critical care medicine · 2020
    Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Matthew HenkelDivision of Pediatric Infectious Diseases.
Jessica PartykaDivision of Pediatric Infectious Diseases.
Alyssa D GregoryDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Erick FornoDivision of Pediatric Pulmonary Medicine.ORCID 0000-0001-6497-9885
Michael H ChoChanning Division of Network Medicine and.
Taylor EddensDivision of Pediatric Infectious Diseases.
Andrew R ToutDivision of Pediatric Infectious Diseases.
Nathan SalamachaDepartment of Developmental Biology.
William HorneRichard K. Mellon Institute for Pediatric Research, and.
Krithika S RaoDivision of Pediatric Cardiology, Department of Pediatrics.
Yijen WuDepartment of Developmental Biology.
John F AlcornDivision of Pediatric Pulmonary Medicine.
Dennis KostkaDepartment of Developmental Biology.
Raphael HirschStead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Juan C CeledónDivision of Pediatric Pulmonary Medicine.
Steven D ShapiroDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.
Jay K KollsRichard K. Mellon Institute for Pediatric Research, and.
Brian T CampfieldDivision of Pediatric Infectious Diseases.
Children's Hospital of Pittsburgh · USPulmonary and Allergy Associates · USBrigham and Women's Hospital · USPediatric Infectious Diseases Society · USPediatrics and Genetics · USUniversity of Iowa · USUniversity of Pittsburgh · US

Funding

Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Training in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3M
Influenza A Inhibits TH17 Host Defense Against Bacterial PneumoniaR01HL107380 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALCORN, JOHN F · 2012 to 2024
$5.4M
PITTSBURGH PEDIATRIC RHEUMATOLOGY TRAINING GRANTT32AR052282 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLLS, JAY K · 2005 to 2014
$1.8M
Role of FSTL-1 in ArthritisR01AI073556 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HIRSCH, RAPHAEL · 2008 to 2011
$1.6M
A Critical Role for Follistatin-like Protein-1 in Lung HomeostasisK08HL128809 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAMPFIELD, BRIAN T · 2015 to 2019
$675k
Antigen discovery and validation in Pneumocystis pneumoniaF30AI114146 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI EDDENS, TAYLOR JOHN · 2014 to 2017
$189k
NHLBI NIH HHS K08 HL128809NHLBI NIH HHS R01 HL107380NHLBI NIH HHS R35 HL139930NHLBI NIH HHS U01 HL089856NIAID NIH HHS F30 AI114146NIAID NIH HHS L40 AI113898NIAID NIH HHS R01 AI073556NIAMS NIH HHS T32 AR052282
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsEndothelial CellsFollistatin-Related ProteinsGene Expression RegulationGene Knockdown TechniquesHumansIn Vitro TechniquesLungMacrophagesMiceMutationNicotianaNuclear Receptor Subfamily 4, Group A, Member 1PhosphorylationPolymorphism, Single NucleotidePositron Emission Tomography Computed TomographyFollistatin-Related ProteinsFSTL1 protein, humanFstl1 protein, mouseNr4a1 protein, mouseNuclear Receptor Subfamily 4, Group A, Member 1Rela protein, mouseSmokeTranscription Factor RelAchronic obstructive pulmonary diseasegene expressionmicro–computed tomographySNP

Identifiers

PMID31834999
PMCPMC7159415
OpenAlexW2995114612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.